Avtor/Urednik		Vidan-Jeras, Blanka
Naslov		Levkocitni aloantigeni pri transplantaciji ledvice
Prevedeni naslov		Leukocyte alloantigens in renal transplantation
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 39, št. Suppl 5
Leto izdaje		2000
Obseg		str. 221-26
Jezik		slo
Abstrakt		Human Leukocyte Antigens consist of glycoprotein chains which contain globular domains. Two of the domains of each HLA molecule interact to form a cleft that binds antigenic peptides. HLA molecules play a central role in the presentation of foreign protein antigens, processed into peptides, to the immune system. Class I molecules, which are expressed on nearly all nucleated cells, present processed endogenous antigens to CD8+ T cells. Class II molecules, which are expressed on a limited number of antigen presenting cells (macrophages, dendritic cells, B cells), present processed exogenous antigens to CD4+ T cells. The rejection of graft is a byproduct of this fundamental role of HLA molecules.
Izvleček		Aloantigeni HLA (Human Leucocyte Antigen) so glikoproteini, ki so oblikovani v globularne domene tako, da tvorita zgornji domeni vsake molekule HLA vdolbino, v katero se usedajo peptidi. Ključna vloga molekul HLA v imunskem odzivu je predstaviti peptide, ki nastanejo pri razkroju antigenov, limfocitom T. Molekule HLA prvega razreda, ki se nahajajo na večini celic z jedrom, vežejo endogene peptide in jih predstavljajo CD8+ limfocitom T. Molekule HLA drugega razreda, ki se nahajajo le na nekaterih celicah, kot so makrofagi, dendritske celice, limfociti B, pa vežejo eksogene peptide in jih predstavljajo CD4+ limfocitom T. Zavrnitev presadka je le stranski učinek osnovne vloge molekul HLA v imunskem sistemu.
Deskriptorji		KIDNEY TRANSPLANTATION TRANSPLANTATION IMMUNOLOGY HLA ANTIGENS HISTOCOMPATIBILITY TESTING