Avtor/Urednik		Pavelić, Jasminka; Lamovec, Janez; Novak, Janez; Gall-Trošelj, Koraljka; Kapitanović, Sanja; Pavelić, Krešimir
Naslov		Collision tumour in the pelvic cavity: rectal leiomysarcoma and prostate adenocarcinoma
Tip		članek
Vir		J Cancer Res Clin Oncol
Vol. in št.		Letnik 126, št. 2
Leto izdaje		2000
Obseg		str. 95-100
Jezik		eng
Abstrakt		We report a rare and, to our knowledge, as yet u derscribed type of collision tumour - rectal leiomyosarcoma and prostate adenocarcinoma. Our study also provides the first data on molecular alterations (polymerase chain reaction/loss of heterozygosity (LOH) analysis) of the APC, NF-1, DCC, p53, nm23-H1 and BRCA-1 genes in the two components of the collision tumour. None of the genes examined in this study expressed LOH in the prostate carcinoma component of the collision tumour. By contrast, in the leiomyosarcoma component, LOH was found at the DCC and p53 genes, proving that these two tumours did not arise from the same stem cell but represent two different neoplastic growths.
Deskriptorji		PROSTATIC NEOPLASMS ADENOCARCINOMA LIOMYSARCOMA RECTAL NEOPLASMS IMMUNOHISTOCHEMISTRY FLOW CYTOMETRY LOSS OF HETEROZYGOSITY MIDDLE AGE