Avtor/Urednik		Jazbec, Anja
Naslov		Povezava med rupturo srčne stene pri akutnem srčnem infarktu in trombolitičnim zdravljenjem
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 33
Jezik		slo
Abstrakt		Heart rupture is a severe mechanical complication of acute myocardial infarction (AMI). Despite improvement in treatment of AMI in the past years, mortality due to heart rupture remains high. There is little knowledge about the influence of medical treatment of AMI on heart rupture. The aim of our work was to establish the relation between thrombolytic treatment of AMI and incidence and clinical course of heart rupture. The study included patients with AMI, treated in Centre for Intensive Internal Medicine between January 1st, 1983 and December 31st, 1999. Patient's data were retrieved from the computerized database of the Centre, from autopsy recording of the Institute of pathology and Institute of Forensic Medicine, and from patients' medical records. Between January 1st, 1983 and December 31st, 1999, we treated 7204 patients with AMI; among them, 296 had heart rupture. Patients with heart rupture were often without previous AMI (p<0,0001; chi-square test), women (<0,0001; chi-square test), patients with hypertension (p<0,0001; chi-square test), and they were older than the rest of patients with AMI (p<0,0001; Mann-Whitney test). In 2647 patients, treated with thrombolysis, there was a lower incidence of heart rupture (3,22%) than in 4632 patients who did not receive thrombolysis (4,63%; p<0,0001, chi-square test). Heart rupture occurred earlier after onset of AMI symptoms in patients treated with thrombolysis (38,9 +- 70,2 hours; arithmetic mean and standard deviation) than in patients with heart rupture who did not receive thrombolytic treatment (85,5 +- 133,8 hours; p<0,0001). Among patients with AMI, those with heart rupture received thrombolytic treatment later (244 +- 137 minutes after onset of AMI symptoms; aritmetic mean, stamdard deviation) than patients without heart rupture (227 +- 163 minutes after onset of AMI symptoms); however, this difference was statistically not significant. (Abstract truncated at 2000 characters).
Deskriptorji		MYOCARDIAL INFARCTION THROMBOLYTIC THERAPY HEART RUPTURE, POST-INFARCTION RISK FACTORS HYPERTENSION