Avtor/Urednik		Berkmen, Ferhart; Peker, Ahmet Fuat; Basay, Sinan; Ayyildiz, Ali; Arik, Ali Ihsan
Naslov		Synchronous and metachronous bilateral germ cell tumours of the testis
Prevedeni naslov		Sinhroni in metahroni bilateralni germinalni tumorji testisov
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 34, št. 4
Leto izdaje		2000
Obseg		str. 363-8
Jezik		eng
Abstrakt		Background. We reported fourteen patients with bilateral testicular tumors, and discussed the need for contralateral testicular biopsy during orchiectomy to detect carcinoma in situ (CIS). Patients and methods. Fourteen patients with bilateral testicular tumours were reviewed in order to establish the incidence, histologic findings, predisposing factors, interval between the development of two primaries, type of treatment administered and the overall outcome. Results. Bilateral tumors were identified fourteen times between 1984 and 1996. The tumours occurred simultaneously in five patients, and a contralateral malignancy developed in the others after a time ranging between 6 and 107 months. The most frequent histologic diagnosis was seminoma and was confirmed in 10 cases. Four patients had a history of undescended testis. One patient also had persistent muellerian duct syndrome. All patients were initially treated with radical orchiectomy. According to their stage, all patients were treated with radiotherapy and/or chemotherapy. Four patients died in the period between 6 and 33 months after the diagnosis. The remaining 10 are still alive with, no evidence of disease. Conclusions. The second tumor is diagnosed more often due to prolonged follow-up examinations; periodic self-examination by patients; ultrasonography of the testis; tumour markers AFP and beta-HCG and a contralateral testicular biopsy during orchiectomy. CIS of the contralateral testis evolves into invasive cancer in probably most of the patient germ cell tumours and usually cured by radiotherapy. (Abstract truncated at 2000 characters.)
Izvleček		Pregledali smo 14 bolnikov z bilateralnim tumorjem testisov in proučevali, ali je potrebno med orkidektomijo opraviti tudi kontralaterno biopsijo testisov za odkrivanje karcinoma in situ. Bolniki in metode. Z raziskovanjem teh 14 bolnikov z bilateralnim tumorjem testisov smo želeli ugotoviti incidenco, histološke podatke, napovedane dejavnike, časovno razliko med nastankom enega in drugega primernega karcinoma, način zdravljenja in končni uspeh. Rezultati. V letih med 1984 in 1996 smo odkrili 14 primerov bilateralnih tumorjev. Pri 5 bolnikih so se tumorji pojavili hkrati, pri ostalih pa se je kontralateralni tumor pojavil s časovnim zamikom od 6 do 107 mesecev. Najpogostejša histološka diagnoza je bila seminom, ki je bil ugotovljen v 10 primerih. Pri 4 bolnikih je bil ugotovljen retiniran testis, pri enem pa sindrom perzistentnega Muellerjevega voda. Pri vseh bolnikih je bila opravljena radikalna orkidektomija. Z ozirom na stadij bolezni so bili vsi bolniki zdravljeni z obsevanjem in/ali kemoterapijo. Štirje bolniki so umrli v času od 6 do 33 mesecev po diagnozi. Preostalih 10 bolnikov je še vedno živih in brez znakov bolezni. Zaključki. Diagnoza sekundarnega tumorja je danes pogostejša zaradi daljšega obdobja, določenega za nadzor bolezni, rednih samopregledovanj bolnikov, ultrazvočnega pregleda testisov, uporabe tumorski markerjev AFP in HCG ter biopsije kontralateralnega testisa med orkidektomijo. Karcinom in situ na kontralateralnem testisu skoraj pri vseh obsevanih bolnikih z germinalnim rakom napreduje v invazivni tumor. (Izvleček prekinjen pri 2000 znakih.)
Deskriptorji		TESTICULAR NEOPLASMS GERMINOMA ORCHIECTOMY CARCINOMA IN SITU