Avtor/Urednik		Vesnaver, Aleš; Mekjavić, Igor B; Budihna, Marjan
Naslov		Vloga hiperbarične oksigenacije pri zdravljenju poobsevalnih okvar
Prevedeni naslov		The role of hyperbaric oxygenation in treatment of post-irradiation injuries
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 69, št. 11
Leto izdaje		2000
Obseg		str. 739-44
Jezik		slo
Abstrakt		Background. As therapy of post-irradiation injuries with hyperbaric oxygenation (HBO) is a new field in Slovenia, the following study was conducted to evaluate its usefulness and effectiveness in patients who had been previously irradiated for carcinomas of the oral cavity and pharynx. Patients and methods. Patients with post-irradiation injuries treated with HBO were compared with those treated without HBO. In this way, two groups of patients with post-irradiation caries (PIC) who needed dental extractions were compared, the test group (n=5) being treated with the aid of HBO, and the control group (n=5) without HBO. Similarly, two groups of patients with osteoradionecrosis (ORN) of the mandible were compared, again the test group (n=5) treated with HBO, and the control group (n=7) without HBO. A comparison was conducted between matching groups regarding the final result and time of treatment, the number of hospitalisations, the total number of hospital days, and the total price of treatment. Results. The final result and time of treatment were statistically significantly (p<0.01) better in the HBO group, both in PIC and ORN patients, as compared to controls. The total price of treatment was significantly (p<0.05) greater in the HBO group of patients with PIC, and insignificantly smaller in the HBO group of patients with ORN. Conclusions. Based on the results, it is concluded that HBO therapy improves therapy of post-irradiation injuries.
Izvleček		Izhodišča. Zdravljenje poobsevalnih okvar s hiperbarično oksigenacijo (HBO) je v Sloveniji še novost, zato smo s pričujočo raziskavo želeli oceniti njeno koristnost in učinkovitost pri bolnikih, ki so bili obsevani zaradi karcinoma v ustni votlini in žrelu. Bolniki in metode. Primerjali smo bolnike s poobsevalnimi okvarami, ki so bili zdravljeni s HBO, z bolniki s poobsevalnimi okvarami, ki so bili zdravljeni brez HBO. Primerjali smo dve skupini bolnikov s poobsevalnim kariesom (POK), ki smo jim ekstrahirali zobe, preiskovana skupina (n=5) je bila zdravljena s HBO, kontrolna skupina (n=5) pa brez HBO. Enako smo primerjali med seboj dve skupini bolnikov z osteoradionekrozo (ORN) mandibule, preiskovana skupina (n=5) je bila spet zdravljena s HBO, kontrolna skupina (n=7) pa brez HBO. Med ustreznima skupinama smo primerjali končni rezultat in čas zdravljenja, število hospitalizacij, skupno število hospitalnih dni ter ceno celotnega zdravljenja. Rezultati. Izkazalo se je, da sta bila končni rezultat in čas zdravljenja v skupini s HBO statistično značilno (p<0,01) bolj ugodna, tako pri bolnikih s POK kot pri bolnikih z ORN. Cena celotnega zdravljenja je bila statistično značilno (p<0,05) višja v skupini s HBO pri bolnikih s POK in statistično neznačilno nižja v skupini s HBO pri bolnikih z ORN. Zaključki. Na osnovi rezultatov lahko zaključimo, da podporno zdravljenje s HBO izboljša možnosti zdravljenja poobsevalnih okvar.
Deskriptorji		RADIATION INJURIES RADIOTHERAPY HYPERBARIC OXYGENATION XEROSTOMIA DENTAL CARIES OSTEORADIONECROSIS TREATMENT OUTCOME EVALUATION STUDIES