Avtor/Urednik		Hočevar-Boltežar, Irena; Žargi, Miha
Naslov		Klinični potek papilomatoze grla
Prevedeni naslov		Clinical course of laryngeal papillomatosis
Tip		članek
Vir		In: Gale N, Žargi M, editors. Epithelial tumours of the head and neck. Proceedings of the 31st memorial meeting for professor Janez Plečnik under the auspices of the European society of pathology; 2000 Dec 7-8; Ljubljana. Ljubljana: Faculty of medicine, Institute of pathology,
Leto izdaje		2000
Obseg		str. 117-21
Jezik		slo
Abstrakt		The purpose of the study was to correlate the clinical course of laryngeal papillomatosis with the histopathologic findings of the removed papillomas. The authors investigated the role of infection with HPVl6/18 in the pathogenesis of risky atypical epithelial hyperplasia or malignant transformation of the papillomas. Among 123 patients; abnormal and/or atypical epithelial hyperplasia was found significantly more often in the papillomas of the patients with recurrent disease than in the patients in whom only one surgical procedure was necessary for cure: Laryngeal carcinoma appeared 9 times more often in adult patients with recurrent papillomatosis and risky epithelial hyperplasia than in the patients with recurrent disease without risky epithelium. Carcinomatous transformation of the laryngeal papillomatosis was detected always in the patients with adult type of disease. The correlation between HPV 16/18 infection and development of risky epithelium or carcinomatous transformation of the papillornas was not proven.
Deskriptorji		LARYNGEAL NEOPLASMS PAPILLOMA PAPILLOMAVIRUS, HUMAN TREATMENT OUTCOME