Avtor/Urednik | Meden-Vrtovec, H; Tomaževič, T; Verdenik, I | |
Naslov | Infertility treatment by in vitro fertilization in patients with minimal or mild endometriosis | |
Tip | članek | |
Vir | Clin Exp Obstet Gynecol | |
Vol. in št. | Letnik 27, št. 3-4 | |
Leto izdaje | 2000 | |
Obseg | str. 191-3 | |
Jezik | eng | |
Abstrakt | Purpose: To estimate the clinical effectiveness of in vitro fertilization treatment in patients with minimal or mild endometriosis (stage I and II) in comparison to the patients with tubal infertility in terms of fertilization, pregnancy and livebirth rates. Methods: Retrospective analysis of the outcome of IVF-ET in 612 cycles of the patients with endometriosis (389 stimulated with HMG/HCG and 223 co-treated with GnRH-a) and in 7,339 cycles of the patients with tubal infertility (5.520 stimulated with HMG/HCG and 1,819 co-treated with GnRH-a). Results: Regardliness of the type of ovarian stimulation, the fertilization rate per treated cycle was practically the same in both groups (endometriosis 81.4% vs tubal infertility 84,2%; p=0.07). However, in the endometriosis group the pregnancy rate was higher (25.3% vs 18.9%; p=0.000), and so was the livebirth rate (19.0% vs 14.2%; p=0.003). Considering the type of ovarian stimulation, the fertilization rate in the endometriosis group was almost the same in the HMG/HCG (81.2%) and in the GnRH-a co-treated cycles (81.6%), and did not differ from that in the tubal infertility group (83.6% in the HMG/HCG vs 85..9% in the GnRH-a cycles). In the GnRH-a co-treated cycles the pregnancy rate and the livebirth rate were not significantly higher in the endonmetriosis group than in the tubal infertility group (27% and 20.2% vs 22.2% and 17.5%). In the HMG/HCG stimulated cycles the pregnancy rate was significantly higher in the endometriosis than in the tubal infertility group (24.3% vs 17.7%; p=0.004), and so was the liverbirth rate (18.4% vs 13.0%; p=0.008). Conclusion: In patients with minimal or mild endometriosis the IVF-ET procedure is at least as effective as in patients with tubal infertility. | |
Deskriptorji | INFERTILITY, FEMALE ENDOMETRIOSIS FERTILIZATION IN VITRO OVULATION INDUCTION EMBRYO TRANSFER PREGNANCY RETROSPECTIVE STUDIES MENOTROPINS GONADOTROPINS, CHORIONIC GONADORELIN TREATMENT OUTCOME |