Avtor/Urednik		Kržišnik-Zorman, Simona
Naslov		Mioglobinemija u trombolitičkom liječenju akutnog infarkta miokarda
Tip		monografija
Kraj izdaje		Rijeka
Založnik		Sveučilište u Rijeci, Medicinski fakultet
Leto izdaje		1994
Obseg		str. 51
Jezik		cro
Abstrakt		Myoglobin is an intracellular hem-protein. The aim of the study was to compare the time course of serum myoglobin concentration (Mb) in patients with successful and unsuccessful thrombolytic treatment of acute myocardial infarction (AMI). Forty-seven patients with AMI treated with brief high-dose streptokinase or urokinase were included. Reperfusion was achieved in 29 patients, in 18 there was no reperfusion. In reperfused group the time to peak Mb (tMb was 120 +- 50 minutes (median +- quartile deviation). Maximal rate of Mb rise (Va max) was 30.3 +- 13.2 microg/ml min. The time required for Mb to rise from 50% to 100% of peak value (t50-100) was 41 +- 15 minutes. The maximal rate of Mb decline (Vd max) was 11.4 +- 6.4 microg/ml min. The time required for Mb to decline from peak to 50% (t100-50) was 93 +- 26 minutes. In nonreperfused group tMb max was longer (360 +- 120 minutes), Va max was smaller (4.3 +- 2.5 microg/ml min), Vd max was smaller (1.9 +- 0.9 microg/ml min). T50-100 was 193 +- 104 minutes, t100-50 was 235 +- 102 minutes. The differences in all described parameters were statistically significant (p < 0.001). Three fold increase of Mb in first 120 minutes of thrombolytic treatment was 89% sensitive, 83% specific for reperfusion. Prognostic value was 89%. 25% decline of Mb in first hour after peak Mb was 89% sensitive and 100% specific for reperfusion, prognostic value was 89%. The time course of Mb differs in reperfused and nonreperfused group of patients with AMI. We consider it an early noninvasive sign of reperfusion which allows us to assess the success of thrombolysis in first 2 hours of treatment.
Deskriptorji		MYOCARDIAL INFARCTION MYOGLOBIN THROMBOLYTIC THERAPY STREPTOKINASE UROKINASE ACUTE DISEASE BLOOD PROTEINS MYOCARDIAL REPERFUSION