Avtor/Urednik		Obreza, Aleš; Sollner, Marija
Naslov		Mannichove baze s protitumornim in protimikrobnim delovanjem
Prevedeni naslov		Mannich bases with antitumor and antimicrobial activity
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 51, št. 4
Leto izdaje		2000
Obseg		str. 575-84
Jezik		slo
Abstrakt		Mannich bases of steryl ketons are a novel group of compounds with antitumor activity. New drugs from this field are necessary because currently used antitumor agents are nonselective and have numerous side effects. At first Mannich bases were used to improve aqueous solubility of compounds currently in use, but later enhanced activity of some compounds with dialkylamino methyl group was observed. The most potent styryl keton derivatives have the activity similar to antitumor compounds currently in use, while they had no cross-resistance. Recently there were reports of antibacterial and antifungal activity of some Mannich bases.
Izvleček		Zaradi velike pogostosti rakavih obolenj in neselektivnosti ter številnih stranskih učinkov trenutno uporabljanih zdravilnih učinkovin potekajo intenzivne raziskave na področju iskanja novih učinkovin proti rakavim obolenjem. Sem sodijo tudi Mannichove baze stiril ketonov. Sprva so se Mannichove baze uporabljale za izboljšanje vodotopnosti že obstoječih zdravilnih učinkovin, kasneje pa se je prav pri tej skupini pokazala večja aktivnost pri spojinah z dialkilaminometilno skupino. Najboljše spojine te serije so po aktivnosti primerljive s trenutno uporabljanimi protitumornimi učinkovinami. Prednost je tudi ta, da pri njih niso opazili navzkrižne rezistence. Poleg protitumornega delovanja v zadnjem času poročajo o protibakterijskem in fungicidnem delovanju Mannichovih baz.
Deskriptorji		MANNICH BASES ANTINEOPLASTIC AGENTS ANTIBIOTICS ANTIFUNGAL AGENTS STYRENES KETONES PIPERIDINES PIPERIDONES