Avtor/Urednik		Petelin, M; Pavlica, Z; Ivanuša, T; Šentjurc, M; Skalerič, U
Naslov		Local delivery of liposome-encapsulated superoxide dismutase and catalase suppress periodontal inflammation in beagles
Tip		članek
Vir		J Clin Periodontol
Vol. in št.		Letnik 27, št. 12
Leto izdaje		2000
Obseg		str. 918-25
Jezik		eng
Abstrakt		Background, aims: The purpose of this study was to evaluate the influence of oxygen free radical scavengers on periodontal inflammation and healing process. Method: Experimental periodontitis was induced by elastic ligatures around premolars (P2, P3, P4) and 1st molars (M1) in the upper and lower jaws of 15 beagle dogs. 9 months after the beginning of the experiment, the ligatures were removed. After 3 weeks of stabilization period, all teeth were supragingivally scaled. The animals were divided into 3 groups of 5 dogs. The 1st group received a liposome-encapsulated superoxide dismutase (SOD), the 2nd group a liposome-encapsulated catalase (CAT) and the 3rd group received both enzymes encapsulated in liposomes. 4 treatment modalities were tested in each group; i.e., supragingival scaling only (1), supragingival scaling and enzymes (2), supra- and sub-gingival scaling and root planing (3) and supra- and sub-gingival scaling and root planing with subgingival application of enzymes (4). Enzymes were delivered subgingivally on a daily basis for a period of 6 weeks. Gingival index (GI), probing depth (PD), clinical attachment level (CAL), radiographic analysis and the histological evaluation were performed.Results: Around the teeth with scaling and root planing followed by the application of SOD, the greatest suppression of gingival inflammation (GI = 1.8+/- 0.1 before versus GI = 1.2 +/- 0.2 after treatment) (p<0.003), the smallest size of connective tissue infiltrate (5.5 +/- 4.3%) (p<0.01), the greatest reduction of PD (PD= 3.2 +/- 1.0 mm before versus 2.00.7 mm after treatment) (p<0.001), and gain of CAL (CAL=3.0 +/- 1.7 mm before versus CAL=2.4 +/- 1.1 mm after treatment) (p<0.001) were observed. In addition, radiographic analysis showed the greatest alveolar bone apposition in the group of teeth treated with scaling and root planing followed by subgingival application of SOD or both enzymes (p<0.001). (Abstract truncated at 2000 characters.)
Deskriptorji		ALVEOLAR BONE LOSS ANTIOXIDANTS CATALASE SUPEROXIDE DISMUTASE PERIODONTITIS DOGS ANALYSIS OF VARIANCE DENTAL SCALING LIPOSOMES PERIODONTAL INDEX