Avtor/Urednik		Čižman, Milan; Pokorn, Marko; Seme, Katja; Oražem, Andreja; Paragi, Metka
Naslov		The relationship between trends in macrolide use and resistance to macrolides of common respiratory pathogens
Tip		članek
Vir		J Antimicrob Chemother
Vol. in št.		Letnik 47, št. 4
Leto izdaje		2001
Obseg		str. 475-7
Jezik		eng
Abstrakt		The correlation between increased macrolide consumption and the resistance of Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis to macrolides in Slovenia from 1994 to 1999 was evaluated. The outpatient consumption of macrolides increased from 1.89 to 3.84 defined daily doses (DDD)/1000 inhabitants/day during the observation period. This increase in macrolide consumption was paralleled by a steady increase in macrolide resistance in S. pyogenes (from 0 to 7.4%, r =0.90, P=0.014) and upper respiratory S. pneumoniae isolates (from 0 to 9%, r =0.82, P=0.044). In other pathogens studied, no significant increase was detected.
Deskriptorji		RESPIRATORY TRACT INFECTIONS ANTIBIOTICS, MACROLIDE DRUG RESISTANCE, MICROBIAL STREPTOCOCCUS PNEUMONIAE STREPTOCOCCUS PYOGENES HAEMOPHILUS INFLUENZAE MORAXELLA (BRANHAMELLA) CATARRHALIS DRUG UTILIZATION ERYTHROMYCIN AZITHROMYCIN SLOVENIA