Avtor/Urednik		Galvani, Vesna
Naslov		Pomen receptorja faktorja tumorske nekroze alfa tipa I pri raku in revmatoidnem artritisu
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 98
Jezik		slo
Abstrakt		The importance of cytokines is well determined in connection with malignant diseases and autoimmunologic diseases like rheumatoid arthritis (RA). On the other hand, the importance of neutralizing factors of the cytokines are not well known. Tumor necrosis factor (TNFalpha) is a member of a cytokine family and is produced by stimulated mononuclear cells and some other cells. TNFalpha has been discovered because of its ability to provoke the necrosis of tumors. TNFalpha is cytotoxic and can in some circumstances activate proinflammatory factors. In accordance to the production of TNFalpha the two TNF receptors, p55 and p75 are produced. Both proteins can be found in the human sera or urine in the soluble form and are supposed to be the natural inhibitors of the cytokine. Both receptors are expressed on nearly every cell membrane with the exception of erythrocytes and resting T lymphocytes. To determine the serum values of soluble p55 and to investigate its prognostic value, we examined the sera of 109 patients with no recurrent disease after surgical removal of melanoma, 52 patients with metastatic melanoma and 46 patients with ovarian carcinoma. The sera values of soluble p55 were compared with the normal values (healthy controls). According to our findings, the sera concentrations increased as the disease progressed. The patients with metastatic melanoma had higher values of soluble p55 than the control group and melanoma patients without recurrence. The results of the present study showed that in the case of melanoma the level of soluble p55 in serum might give an additional information to the clinician when predicting the outcome of the treatment with chemoimmuno therapy. (Abstract truncated at 2000 characters)
Deskriptorji		MELANOMA NEOPLASM METASTASIS ARTHRITIS, RHEUMATOID TUMOR NECROSIS FACTOR RECEPTORS, TUMOR NECROSIS FACTOR SEQUENCE ANALYSIS, DNA POLYMERASE CHAIN REACTION RNA, MESSENGER ANTIBODIES, MONOCLONAL METHOTREXATE OVARIAN NEOPLASMS TREATMENT OUTCOME SYNOVIAL FLUID