Avtor/Urednik		Strle, Franc
Naslov		Ateroskleroza in okužbe z bakterijo Chlamydia pneumoniae
Prevedeni naslov		Atherosclerosis and infections with Chlamydia pneumoniae
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 40, št. Suppl 2
Leto izdaje		2001
Obseg		str. 81-90
Jezik		slo
Abstrakt		This review article gives data on the association between atherosclerosis and infection with Chlamydia pneumoniae. The association has been suggested by the findings of several epidemiological and seroepidemiological studies, supported by the presence of C. pneumoniae in atherosclerotic vessel lesions and by the findings of in vitro studies, and demonstrated in animal studies by the induction of (atherosclerotic) inflammatory changes and/or enhancement of the influence of traditional atherosclerosis risk factors on the course of atherosclerosis, as well as by prevention of the lesions by early antibiotic treatment. Several clinical studies on the influence of antibiotic treatment on the course of coronary artery disease are in progress. While there is no doubt about the association between atherosclerosis and C. pneumoniae infection, the possible etiological role of this infection remains to be established. C. pneumoniae infections might have been the etiological agent of atherosclerosis, one of the risk factors or just coincidental to atherosclerosis; this last possibility seems rather remote. There have been no reliable reasons for routine treatment of coronary heart disease with antibiotics in everyday clinical practice.
Izvleček		Avtor v pregledni obliki prikazuje podatke o povezavi med okužbo z bakterijo Chlamydia pneumoniae in aterosklerozo. To povezavo nakazujejo ugotovitve številnih epidemioloških oziroma seroepidemioloških raziskav, podpirajo najdbe C. pneumoniae v ateromatoznih lehah pri ljudeh in ugotovitve o vplivih C. pneumoniae na različne celice in vitro ter potrjujejo ugotovitve na poskusnih živalih, pri katerih so z okužbo s C. pneumoniae uspeli sprožiti aterosklerozo ali pospešiti oziroma ojačati vpliv drugih dejavnikov tveganja za nastanek ateroskleroze, z zdravljenjem z antibiotiki kmalu po okužbi pa preprečiti bolezen. Potekajo tudi klinične raziskave, ki ocenjujejo vpliv antibiotikov na potek koronarne bolezni. Zaenkrat o povezavi med okužbo s C. pneumoniae in aterosklerozo ni več posebnih dvomov, odprto pa ostaja vprašanje, ali je okužba s C. pneumoniae in njena prisotnost v ateromskem tkivu vzrok ateroskleroze, eden od bolj ali manj pomembnih dejavnikov tveganja za aterosklerozo ali le slučajna najdba, ki z aterosklerozo nima nikakršne povezave. Čeprav je zadnja možnost vse manj verjetna, pa za zdravljenje bolnikov s koronarno boleznijo z antibiotiki v vsakdanji klinični praksi še ni utemeljenih razlogov.
Deskriptorji		ATHEROSCLEROSIS CHLAMYDIA INFECTIONS CHLAMYDIA PNEUMONIAE MYOCARDITIS ENDOCARDITIS, BACTERIAL