Avtor/Urednik     Pavčnik, Dušan; Uchida, Barry T; Timmermans, Hans; Corless, Christoper L; Loriaux, Marc; Keller, Frederick S; Roesch, Josef
Naslov     The square stent-based large vessel occluder: an experimental pilot study
Tip     članek
Vir     J Vasc Interv Radiol
Vol. in št.     Letnik 11, št. 9
Leto izdaje     2000
Obseg     str. 1227-34
Jezik     eng
Abstrakt     Purpose: The purpose of this study is in vitro and in vivo experimental evaluation of a square stent-based vascular occlusion device for large vessels. Materials and methods: Square stent-based large vessel occluders (LVO) 5 mm-50 mm in size were constructed from stainless-steel square stents covered by porcine small intestine submucosa (SIS). The LVOs with two back-side barbs were delivered through a guiding catheter. The LVOs with two back-side barbs and two frontal barbs were front-loaded and delivered coaxially. A pusher with a retention mechanism at its end was used for deployment. In vitro testing for competency was performed with use of a flow model with pressure increases. In an experimental pilot study in seven pigs and five dogs, 16 LVOs were placed into the aorta (n = 4), common iliac artery (n = 2), pulmonary artery (n = 4), and medial sacral artery (n = 6). Four animals received two LVOs in different locations. Angiography was performed before and after placement of each LVO. Animals were followed for as long as 3 months with use of angiography and were then killed for gross and histologic evaluation. Results: In vitro LVOs with two and four barbs were easily collapsed and pushed through or front-loaded into guiding catheters (6-F for a 5-mm occluder, 10-F for a 50-mm occluder). A 20-mm LVO adapted to tubular structures 10-15 mm in diameter, forming polygons 17-18.5 mm in length. In the flow model, LVOs endured pressure increases to 300 mm Hg. In vivo, the LVOs self-expanded and adapted to the vessel without migration in all cases. The locking pusher allowed precise LVO placement and engagement of its barbs into the vessel wall before complete deployment, preventing dislodgment by blood flow. Complete arterial occlusion occurred within 10-20 minutes and arteries remained occluded until the animal was killed in all cases. (Abstract truncated at 2000 characters).
Deskriptorji     EMBOLIZATION, THERAPEUTIC
STENTS
DOGS
STAINLESS STEEL
SWINE
PROSTHESIS DESIGN
PILOT PROJECTS
INTESTINAL MUCOSA
ANGIOGRAPHY
ILIAC ARTERY
AORTA
PULMONARY ARTERY
AUTOPSY