Avtor/Urednik		Strojan, Primož; Budihna, Marjan; Šmid, Lojze; Vrhovec, Ivan; Škrk, Janez
Naslov		Urokynase-type plasminogen activator, plasminogen activator inhibitor type 1 and cathepsin D: analysis of their prognostic significance in squamous cell carcinoma of the head and neck
Tip		članek
Vir		Anticancer Res
Vol. in št.		Letnik 20, št. 5
Leto izdaje		2000
Obseg		str. 3975-81
Jezik		eng
Abstrakt		Background: The aim of the study was to evaluate the prognostic significance of tumour and serum concentrations of urokinase-type plasminogen activator (uPA), its type 1 inhibitor (PAI-1) and cathepsin D (Cath D) in patients with squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods: Determinations of uPA and PAI-1 were made using enryme-linked immunosorbent assays in tumour and serum samples of 47 and 32/47 patients, respectively. For the determination of tumour (94 patients) and serum (34/94 patients) Cath D concentrations, an immunoradiometrc assay was used. Results: In an univariate survival analysis, the risk of disease recurrence and SCCHN-related death was significantly higher in the patients with high uPA (P=0.046, P=0.0101 tumours, compared to those with low uPA tumours. In addition, the high serum levels of uPA correlated positively with the rate of relapse (P=0.007), but not with the mortality rate (P=0.200). There was no statistically significant difference between low and high PAI-1 groups, regarding either tumour or serum concentration of the inhibitor, and between low and high Cath D tumours. Low Cath D serum levels appeared to be related to longer disease-free interval (P=0.055), but not to disease-specific survival (P=0.120). Conclusions: The tumour levels of uPA, as well as serum levels of uPA and Cath D could potentially predict the survival probability of patients with SCCHN. However, the strength of this association remains to be investigated on a larger and more homogenous group of patients.
Deskriptorji		HEAD AND NECK NEOPLASMS CARCINOMA, SQUAMOUS CELL PLASMINOGEN ACTIVATOR INHIBITOR 1 UROKINASE CATHEPSIN D SURVIVAL ANALYSIS NEOPLASM STAGING