Avtor/Urednik		Zega, A; Trampuš-Bakija, A; Fortuna, M; Stegnar, M; Tschopp, TB; Steiner, B; Urleb, U
Naslov		Novel thrombin inhibitors with azaphenylalanine scaffold
Tip		članek
Vir		Pharmazie
Vol. in št.		Letnik 56, št. 9
Leto izdaje		2001
Obseg		str. 683-5
Jezik		eng
Abstrakt		In this paper the synthesis and antithrombotic activity of a series of novel thrombin inhibitors with azaphenylalanine scaffold are described. By systematic structural modifications for this series we have identified optimal groups for achieving nanomolar potency, that led us to potent inhibitors of thrombin with Ki values up to 11 nM.
Deskriptorji		ANTICOAGULANTS THROMBIN PARTIAL THROMBOPLASTIN TIME PROTHROMBIN TIME SPECTROPHOTOMETRY, ULTRAVIOLET THROMBIN TIME BLOOD COAGULATION DRUG STABILITY