Avtor/Urednik		Rajer, Elizabeta; Radan, Ivan
Naslov		Spremljanje motorične aktivnosti med obdobji nezaznavne nočne hipoglikemije pri mladostnikih z inzulinsko odvisno sladkorno boleznijo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 62
Jezik		slo
Abstrakt		Backgroand. Hypoglycemia is a common and dangerous complication of insulin-dependent diabetes mellitus (IDDM). Its incidence increases with intensification of the treatment aiming at near- normalization of blood glucose. Hypoglycemia is the major impediment of successful intensive insulin treatment. Nocturnal hypoglycemia is a widespread and important problem in children and adolescents with diabetes and a phenomenon that is difficult to recognize clinically. Hypoglycemic episodes often remain unrecognized but their consequences are not less serious then those caused by symptomatic hypoglicemia. Development of a painless, noninvasive methode to detect unawared nocturnal hypoglycemia would represent a significant improvement in the treatment of diabetes and in the quality of patients' life. Some atempts like morning cortisol/creatinin ratio or EEG monitoring have been made to develop a noninvasive methode to detect night hypoglycemias but none of them was reliable enough. Hypothesis. Our aim was to test the hypothesis that the motor activity, detectable with an activity monitor, corellates with glycemic level (normo-, hipo and hyperglycemia). Patients and methods. Motor activity was observed using wirst actigraphy with simultaneously measurment of blood glucose. Eighteen pediatric patients with IDDM were investigated (mean age 13,3 +- 1,6 years). An antebrachial i.v. line was established and blood was sampled half-hourly from 23:00 to 06:00 by means of special catheter connected to a continous pump. Actimeter was placed on the contralateral wirst to record activity in the same time period. Patients were continuously observed and a protocol of awake periods or hypoglycemic signs was written. Before data analysis we excluded all the periodes of wakefullnes and periodes betwen 05:00 and 06:00 am when the patients started to wake up. (Abstract truncated at 2000 characters).
Deskriptorji		DIABETES MELLITUS, INSULIN-DEPENDENT HYPOGLYCEMIA MOTOR ACTIVITY ADOLESCENCE SLEEP DISORDERS ELECTROENCEPHALOGRAPHY