Avtor/Urednik		Čerček, Miha
Naslov		Sprememba vazomotorne funkcije koronarnih in perifernih arterij pri bolnikih s koronarno aterosklerozo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2000
Obseg		str. 21
Jezik		slo
Abstrakt		Background Endothelial injury and the consequent endothelial dysfunction initiate the atherosclerotic process. One of the manifestations of endothelial dysfunction is attenuation of endothelium dependant vasomotion (EOV). Many studies showed that factors which induce dilator response in presence of intact endothelium, cause less vasodilation and even vasoconstriction in patients with atherosclerosis. This impairment of EOV was observed already in early phases of atherosclerotic process. It seems to involve the entire arterial tree. Function of vascular smooth muscle is also impaired in atherosclerosis. The degree of the impairment can be determined by the evaluation of endothelium non-dependant vasomotion (ENV). ENV is induced by factors acting directly on the vascular smooth muscle, without any endothelial involvement. It is not clear at which stage of atherosclerotic process the ENV becomes impaired. It is also not clear whether the impairment of ENV is generalised or limited to the sites of atherosclerotic plaques. In our study, we compared EOV with ENV, and evaluated the generalisation of their impairment in patients with coronary artery disease. Methods We examined 15 patients with coronary artery disease. EOV was assessed with the cold pressor test (CPT) and with the cuff dilation test, while nitroglycerin (200 micro g intracoronary bolus injection and 0,4mg sublingually) was used to test ENV. The extent of the atherosclerotic process and the vascular response to provocative stimuli of coronary arteries were determined angiographically, while ultrasound measurements were performed for evaluating the changes in brachial artery. Results CPT caused elevation of heart rate and arterial blood pressure. Coronary arteries constricted in response to CPT, while brachial artery diameter did not change significantly. Aplicarion of nitroglycerin lowered arterial blood pressure and increased heart rate. (Abstract truncated at 2000 characters).
Deskriptorji		CORONARY DISEASE CORONARY ARTERIOSCLEROSIS CORONARY ANGIOGRAPHY BRACHIAL ARTERY NITROGLYCERIN HEART RATE COLD VASOCONSTRICTION VASODILATION BLOOD PRESSURE