Avtor/Urednik		Pfeifer, Marija
Naslov		Sindrom pomanjkanja rastnega hormona pri odraslem - učinki nadomestnega zdravljenja
Prevedeni naslov		Syndrome of growth hormone deficiency in adults - effects of growth hormone replacement therapy
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 70, št. 5
Leto izdaje		2001
Obseg		str. 295-9
Jezik		slo
Abstrakt		Background. After the cessation of longitudinal growth, growth hormone (GH) continues to subserve an important role in the regulation of body metabolism (stimulation of lipolysis and lipid oxidation, protein synthesis, insulin antagonism, and sodium and water retention) to optimise body composition and function. Most patients with hypopituitarism exhibit the syndrome of GH deficiency with a number of abnormal features which can be reversed with recombinant GH replacement therapy. Conclusions. GH-deficient patients have decreased lean body mass and bone mineral content, increased fat mass, reduced muscle strength and exercise performance, dyslipidemia and increased prevalence of other risk factors for atherosclerosis. They exhibit increased cardiovascular morbidity and mortality and impaired quality of life. It has been shown that GH replacement normalises body composition and exercise capacity, reverses early atherosclerotic changes in major arteries, improves cognitive functions and quality of life. As the treatment with recombinant GH is life-long and expensive it should be offered to patients who exhibit most symptoms and have heen proven to have severe GH-deficiencv.
Izvleček		Izhodišča. Po končani telesni rasti se rastni hormon (RH) iz hipofize še naprej izloča in z urejanjem presnove (spodbujanjem lipolize, sinteze beljakovin, štedenjem glukoze in zadrževanjem natrija in vode) vzdržuje optimalno telesno sestavo in zmogljivost. Večina bolnikov s hipopituitarizmom ne izloča dovolj RH, zato pri njih nastane sindrom pomanjkanja RH. Odkar je na voljo rekombinantni humani RH, jih lahko uspešno zdravimo z nadomeščanjem RH. Zaključki. Zaradi pomanjkanja RH imajo bolniki zmanjšano mišično in kostno maso, povečano količino maščobnega tkiva, zmanjšano mišično moč in telesno zmogljivost, dislipidemijo in povečano prevalenco drugih dejavnikov ogrožanja za aterosklerozo. Pogosteje zbolevajo in umirajo za srčnožilnimi boleznimi in imajo slabšo kakovost življenja. Nadomeščanje RH pri bolnikih ublaži ali odpravi simptome in znake pomanjkanja RH: normalizira telesno sestavo in zmogljivost, izboljša kognitivne sposobnosti in življenjsko kakovost ter zmanjša dejavnike ogrožanja in zgodnje znake ateroskleroze. Ker je rekombinantni RH drag, uvajamo nadomestno zdravljenje z RH pri bolnikih, ki imajo najbolj izražene bolezenske znake in jim s testi dokažemo hudo pomanjkanje RH.
Deskriptorji		SOMATOTROPIN HYPOPITUITARISM SOMATOTROPINS, RECOMBINANT ADULT