Avtor/Urednik		Miklavčič, Damijan
Naslov		Electrical engineering aspects of electroporation drug and gene delivery
Tip		članek
Vir		Medicon 2001. 9th Mediterranean conference on medical and biological engineering and computing. 2nd Croatian-Slovenian meeting on biomedical engineering. 1st international conference on muscle fibre structure and function. 5th symposium of Croatian society for medical informatics (Medicine informatics 2001). Proccedings of the International federation for medical and biological engineering. Part 1, Part 2; 2001 Jun 12-15; Pula
Leto izdaje		2001
Obseg		str. 16-8
Jezik		eng
Abstrakt		Permeabilizing electric pulses can be advantageously used for DNA electrotransfer in vivo for gene therapy, as well as for drug delivery. In both cases it is essential to know the electric field distribution in the tissues: the targeted tissue must be submitted to electric field intensities above the reversible permeabilization threshold and below the irreversible permeabilization threshold (to avoid cytotoxic effects of the electric pulses). A threedimensional finite element model was built for different electrodes used in various in vivo experiments. Electrodes of different geometries were modelled by applying appropriate boundary conditions in corresponding grid points of the model. The anatomically based model was previously validated by comparing our calculations with magnetic resonance current density imaging and electrochemotherapy for specific electrodes. The observations resulting from the numerical calculations, like mean electtic ffeld magnitude within the tumors are in good correlation with the effectivenes of electrochemtherapy.
Deskriptorji		ELECTROPORATION DRUG DELIVERY SYSTEMS NEOPLASMS