Avtor/Urednik		Tepeš, B; Križman, I; Gorenšek, M; Gubina, M; Orel, I
Naslov		Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer?
Tip		članek
Vir		Aliment Pharmacol Ther
Vol. in št.		Letnik 15, št. 7
Leto izdaje		2001
Obseg		str. 1037-45
Jezik		eng
Abstrakt		Background: Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. Aim: To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. Methods: A total of 77 patients with H. pylori-positive duodenal ulcer were included in a prospective, controlled, double-blind study. All patients received a 7-day treatment with omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and amoxicillin 1000 mg b.d. Patients in the omeprazole group underwent an additional 14-day therapy with omeprazole 20 mg; patients in placebo group received placebo. Endoscopy was performed upon inclusion in the study and after 3 and 8 weeks. Results: Seventy-four patients were eligible for a per protocol analysis after 3 weeks, and 65 after 8 weeks. After 3 weeks, the healing rate was 89% in the omeprazole group and 81% in the placebo group (P=0.51). After 8 weeks, the ulcer healed in 97% of the patients in the total group (95% CI: 92.7-100%). H. pylori was eradicated in 88% of patients in the omeprazole group and in 91% in the placebo group (P=1.0). No statistically significant differences between the groups were found in ulcer-related symptoms or in ulcer healing. Conclusion: In patients with H. pylori-positive duodenal ulcer, a 7-day triple therapy alone is sufficient to control the disease.
Deskriptorji		DUODENAL ULCER HELICOBACTER INFECTIONS HELICOBACTER PYLORI OMEPRAZOLE CLARITHROMYCIN AMOXICILLIN DOUBLE-BLIND METHOD TREATMENT OUTCOME