Avtor/Urednik		Seme, Katja; Poljak, Mario
Naslov		Mehanizmi odpornosti pri po Gramu negativnih bakterijah
Prevedeni naslov		Mechanisms of resistance in Gram-negative bacteria
Tip		članek
Vir		In: Mueller-Premru M, Gubina M, editors. Mikrobi in antibiotiki 2001. Zbornik predavanj Mikrobiološki simpozij z mednarodno udeležbo; 2001 jun 22-23; Ljubljana. Ljubljana: Slovensko zdravniško društvo, Sekcija za klinično mikrobiologijo in hospitalne infekcije,
Leto izdaje		2001
Obseg		str. 39-47
Jezik		slo
Abstrakt		Bacterial resistance to antimicrobial agents can be a result of environment-based and organism-based factors. Organism-based resistance has two subcategories: intrinsic or inherent and acquired resistance. Intrinsic resistance results from the normal genetic, structural, or physiologic state of a microorganism, while acquired resistance results from altered cellular physiology and structure due to changes in the usual genetic makeup of a microorganism. Gram-negative bacteria are in general more resistant to antibiotics and chemotherapeutic agents than gram-positive bacteria, mostly due to their specific cell wall structure. Acquired resistance in gram-negative bacteria as well as in grampositive bacteria results from mutation in a gene located in the host chromosome or a plasmid or from acquisition of a new genetic information by transmission from another bacterial cell, mainly by conjugation or transformation. Basic mechanisms of bacterial resistance to certain antibiotic groups in gram-negative bacteria are presented in the article.
Deskriptorji		GRAM-NEGATIVE BACTERIA DRUG RESISTANCE, MICROBIAL ANTIBIOTICS ANTIBIOTICS, AMINOGLYCOSIDE ANTIBIOTICS, LACTAM TETRACYCLINES SULFONAMIDES QUINOLONES