Avtor/Urednik		Hauer, AC
Naslov		T cell-mediated immune reactions in the gut
Tip		članek
Vir		Slov Pediatr
Vol. in št.		Letnik 7, št. 3
Leto izdaje		2000
Obseg		str. 115-9
Jezik		eng
Abstrakt		The gut-associated lymphoid tissue (GALT) is an integral part of our common mucosal immune system, the mucosa-associated lymphoid tissue (MALT). Both by virtue of absolute lymphocyte numbers and the quantity of immunoglobulin produced, GALT is also the largest lymphoid organ of the body. This is mainly related to the enormous antigen load to which its cells are exposed on a daily basis throughout life. Because of the length of the gastrointestinal tract and the enormous surface area that it covers, the gut is also the main entry site for foreign antigens. Therefore, adequate handling of these antigens by our gastrointestinal immune system is necessary for our survival. Thus, as is the case for the mucosal immune system, the general tone of the gastrointestinal subsystem is one of suppression or down-regulated immune response. However, among the clinically most common functional inadequacies are overreactions to mostly innocuous antigens, i.e. hypersensitivity reactions to food antigens. For two clinical entities, cow's milk sensitive enteropathy (CMSE) and coeliac disease (CoD), where the gastrointestinal tract is the target organ, it is T cell-mediated immunity that has been shown to be centrally involved in the pathogenesis.
Deskriptorji		GASTROINTESTINAL SYSTEM IMMUNITY, MUCOSAL T-LYMPHOCYTES FOOD HYPERSENSITIVITY CELIAC DISEASE