Avtor/Urednik		Vince, Adriana; Begovac, Josip; Kessler, Harald; Rabenau, Holger F; Poljak, Mario; Šiftar, Zoran; Židovec, Snježana; Jeren, Tatjana
Naslov		AIDS-related body cavity-based lymphoma: a case report
Tip		članek
Vir		Acta Cytol
Vol. in št.		Letnik 45, št. 3
Leto izdaje		2001
Obseg		str. 420-4
Jezik		eng
Abstrakt		Background: Body cavity-based lymphomas are rare malignancies in human immunodeficiency virus (HIV)-infected patients, but because of their unusual clinical, morphologic and immunophenotypic features, they are recognized as a distinct subgroup of lymphomas connected to human herpesvirus 8 (HHV-8) infection. Case: A 39-year-old, HIV-positivem homosexual man was admitted to the hospital because of a left-sided pleural effusion that contained malignant lymphoid cells. He responded partially to a low-dose cyclophosphamide/doxorubycin/vincristine/prednisone regimen and died five months after the diagnosis of lymphomas. On cytology, the sediments contained exclusively large, round, neoplastic, lymphoid cells with abundant basophilic cytoplasm and large, round nuclei with prominent nucleoli. Many cels had immunoblastic features, and some had plasmocytoid differentiation. Mitotic figures were numerous. On flow cytometry, the homogenous population of large cells expressed CD45, CD38, HLA-DR and CD7 positivity. Other specific T-, B- and NK-cell markers tested negative. Polymerase chain reaction demonstrated Epstein-Barr virus (EBV) and HHV-8 in the malignant effusion. Conclusion: Primary effusion from lymphoma with molecular evidence of HHV-8 and EBV coinfection represents a distinct clinical and morphologic entity in AIDS patients. However, immunophenotypic markers of malignant clones can be diverse in different cases.
Deskriptorji		ACQUIRED IMMUNODEFICIENCY SYNDROME LYMPHOMA, AIDS-RELATED HERPESVIRUS, KAPOSI'S SARCOMA-ASSOCIATED ADULT FLOW CYTOMETRY POLYMERASE CHAIN REACTION HERPESVIRUS 4, HUMAN PLEURAL EFFUSION IMMUNOPHENOTYPING