Avtor/Urednik		Dhall, GI; Calder, A; Gomez-Alzugaray, M; Ho, PC; Pretnar-Darovec, A
Naslov		Medical abortion at 57 to 63 days' gestation with a lower dose of mifepristone and gemeprost: a randomized controlled trial
Tip		članek
Vir		Acta Obstet Gynecol Scand
Vol. in št.		Letnik 88, št. 5
Leto izdaje		2001
Obseg		str. 447-51
Jezik		eng
Abstrakt		Objective: To compare the abortifacient efficacy and side-effects of 200 mg and 600 mg of mifepristone, followed by gemeprost 1 mg vaginally, at 57 to 63 days' gestation. Design: Double-blind, randomized controlled trial. Setting: Ten international centers. SUBJECTS: Eight hundred and ninety-six healthy women requesting medical abortion. Interventions: Participants were randomly assigned to receive a single oral dose of mifepristone of either 200 mg or 600 mg followed in 48 h by gemeprost 1 mg vaginally. The allocation sequence was concealed by using a central pharmacy, and double masking was maintained throughout the study. Main outcomemeasures: Complete abortion rate was the principal outcome measure. We also evaluated the incidence of side-effects and time to abort. Results: The complete abortion rate with the lower dose of mifepristone was similar to that with the higher dose (92.4% vs. 91.7%). The relative risk of failure to achieve a complete abortion with the 200 mg dose compared to 600 mg dose was 0.9 (95% CI 0.6-1.4). The timing of the abortion and the incidence of side-effects were comparable in both groups, with the exception of reported nausea at one-week follow-up which was reported more frequently by women in the higher-dose group. Coclusions: The 200 mg dose of mifepristone is equally as effective as the 600 mg dose in the antiprogestogen-prostaglandin regimen for pregnancy termination. With vaginal gemeprost, the abortifacient efficacy of the regimen remains high at 57-63 days' gestation.
Deskriptorji		ABORTION, INDUCED ALPROSTADIL MIFEPRISTONE PREGNANCY ADMINISTRATION, INTRAVAGINAL ABORTIFACIENT AGENTS, NONSTEROIDAL ABORTIFACIENT AGENTS, STEROIDAL CHINA EUROPE GEORGIA (REPUBLIC) DOUBLE-BLIND METHOD DRUG ADMINISTRATION SCHEDULE HONG KONG INDIA PREGNANCY TRIMESTER, FIRST SLOVENIA TREATMENT OUTCOME UNITED STATES