Avtor/Urednik		Rozman, J; Zorko, B; Bunc, M; Žitko, M
Naslov		Stimulation of nerves innervating the dog's pancreas
Tip		članek
Vir		In: Mayr W, Bijak M, Jancik C, editors. Proceedings of the 7th Vienna international workshop on functional electrical stimulation; 2001 Sep 12-15: Vienna. Vienna: Department of biomedical engineering and physics University of Vienna,
Leto izdaje		2001
Obseg		str. 96-9
Jezik		eng
Abstrakt		Our aim was to modulate secretion of insulin and glucagon into the blood of a healthy and diabetic dog with stimulation of nerves innervating the pancreas. The 33-electrode spiral cuffs were implanted in an adult Beagle canine. The first cuff was installed on the vagus nerve, the second one on the splanchnic nerve and the last one on the pancreatic nerve. To cause insulin-dependent Type I diabetes, partial dysfunction of the pancreas, was induced. Nerves were stimulated using biphasic, rectangular current pulses (IOmA, 200micros, 20Hz). Samples from the femoral artery were drawn before the experiment, after Smin and Smin after the stimulation stopped. Results of radioimmunological assay (RIA) of blood samples showed that, in intact pancreas, stimulation of the vagus nerve caused a considerable increase in insulin secretion, not significant change in glucagon secretion. and decrease in C-peptide secretion. Splanchnic nerve stimulation did not cause considerable change in insulin and C-peptide secretion while considerable increse in glucagon secretion was noticed. Pancreatic nerve stimulation did not change considerably the secretion in any of the three hormones. In dysfunctioned pancreas, vagal nerve stimulation caused an increase in insulin and glucagon secretion and minor increase in C-peptide secretion. Splanchnic nerve stimulation caused a minor decrease in insulin secretion, a considerable increase in glucagon secretion. and a small increase in C-peptide secretion. Pancreatic nerve stimulation did not cause considerable change in insulin secretion while minor increase in glucagon and C-peptide secretion was observed.
Deskriptorji		PANCREAS DIABETES MELLITUS, INSULIN-DEPENDENT ELECTRIC STIMULATION INSULIN GLUCAGON DOGS C-PEPTIDE VAGUS NERVE SPLANCHNIC NERVES RADIOIMMUNOASSAY