Avtor/Urednik		Mrevlje, Franc
Naslov		Sladkorna bolezen tipa 2 in metabolični sindrom - dejavnika tveganja za aterosklerotično srčno-žilno bolezen
Prevedeni naslov		Diabetes mellitus type 2 and metabolic syndrome - risk factors for atherosclerotic cardiovascular disease
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 40, št. Suppl 3
Leto izdaje		2001
Obseg		str. 1-10
Jezik		slo
Abstrakt		Diabetes type 2 and impaired glucose tolerance are metabolic diseases frequently associated with arterial hypertension, dyslipidemia, visceral obesity, and atherosclerotic cardiovascular disease. This cluster of diseases is usually called metabolic syndrome, which is an integrative concept, not a disease entity. Each part of metabolic syndrome and different combinations of diseases mentioned above are risk factors for cardiovascular morbidity and mortality in type 2 diabetic patients, which is 2- to 4-fold higher compared with non-diabetics. Diabetes is among five leading causes of death worldwide. Cardiovascular disease is the main cause of death in 70% of patients, 75% of them are patients with coronary heart disease. Diabetic patients without myocardial infarction are at the same risk level as nondiabetic patients after myocardial infarction. Some other epidemiological data and some main putative etiopathogenetic mechanisms for early atherosclerosis in type 2 diabetics as well as some risk factors are briefly described.
Izvleček		Sladkorna bolezen tipa 2 in motena toleranca za glukozo sta presnovni bolezni, pogosto združeni z arterijsko hipertenzijo, dislipidemijo, trebušno debelostjo in aterosklerotično srčno-žilno boleznijo. Ta skupek bolezni imenujemo metabolični sindrom, ki ga razumemo kot integrativni princip in ne kot samostojno bolezen. Vsak del tega sindroma, še posebej pa kombinacije navedenih bolezni, so dejavniki tveganja za srčno-žilno zbolevnost in umrljivost pri sladkorni bolezni tipa 2, ki je 2- do 4-krat večja kot pri osebah brez sladkorne bolezni. Sladkorna bolezen je med 5 najpogostejšimi vzroki smrti. Srčno-žilna bolezen je vzrok smrti pri 70% bolnikov, od teh je v 75 % vzrok koronarna srčna bolezen. Bolniki s sladkorno boleznijo brez prebolelega infarkta srčne mišice so enako ogroženi zaradi koronarne bolezni kot bolniki brez sladkorne bolezni s prebolelim infarktom. Prikazani so še drugi epidemiološki podatki, podani so kratki opisi glavnih domnevnih etiopatogenetičnih dejavnikov in dejavnikov tveganja za nastanke ateroskleroze pri bolnikih s sladkorno boleznijo.
Deskriptorji		DIABETES MELLITUS, NON-INSULIN-DEPENDENT RISK FACTORS HYPERTENSION HYPERLIPIDEMIA OBESITY ATHEROSCLEROSIS INSULIN RESISTANCE HYPERINSULINEMIA