Avtor/Urednik		Poredoš, P
Naslov		Endothelial dysfunction in the pathogenesis of atherosclerosis
Tip		članek
Vir		In: Pathophysiological, clinical and laboratory aspects of thromboembolic disease. Proceedings of the 8th advanced teaching course in thrombosis and haemostasis; 2001 Mar 22-27; Kranjska gora. Ljubljana: University medical center, Department of angiology,
Leto izdaje		2001
Obseg		str. 13-9
Jezik		eng
Abstrakt		Healthy endothelium plays a central role in cardiovascular control. Therefore, endothelial dysfunction (ED); which is characterized by an imbalance between relaxing and contracting factors, procoagulant and anticoagulant substances, and between proinflammatory and antiinflammatory mediators, may play aparticularly significant role in the pathogenesis of atherosclerosis. Endothelial dysfunction is closely related to different risk factors of atherosclerosis, to their intensity and their duration. The involvement of risk factors in ED is also supported by results of interventions studies that showed regression of ED with treatment of risk factors. As risk, factors are commonly accompanied by decreased bioavailabilty of NO, the common denominator of different risk factors which cause ED is most probably increased oxidative stress. Endothelial dysfunction may promote atherogenesis through different mechanisms: increased adherence of monocytes, macrophages and enhanced permeability of the endothelial layer. Further; ED probably plays an important role in the growth of atherosclerotic lesions and in the development of thrombotic complications in late stages of the disease. As ED is a key underlying factor in the atherosclerotic process, markers of endothelial abnormalities have been sought. Detection of ED is based on tests of endothelium-dependent vasomotion (dilation capability of peripheral and coronary arteries) and on circulating markers of endothelial function (endothelin-1, von Willebrand factor, t-PA, PAI, adhesion molecules). Using these tests it is possible to follow the dose - response of harmful effects or risk factors, and the . effects of preventive procedures on vessel wall function.
Deskriptorji		ATHEROSCLEROSIS ENDOTHELIUM, VASCULAR HYPERTENSION RISK FACTORS NITRIC OXIDE VASODILATION ENDOTHELIN-1 VON WILLEBRAND FACTOR