Avtor/Urednik		Drevenšek, Gorazd; Budihna, Metka V
Naslov		Importance of localisation of endothelin receptors in human coronary arteries
Tip		članek
Vir		In: Štiblar-Martinčič D, Petrovič D, editors. Cardiovascular diseases. Proceedings of the 32nd memorial meeting devoted to professor Janez Plečnik, International symposium in memory of professor Rene Favaloro; 2001 Dec 6-8; Ljubljana. Ljubljana: Medical faculty,
Leto izdaje		2001
Obseg		str. 149-56
Jezik		eng
Abstrakt		Endothelins, discovered in 1988, are the most potent endogenous vasoconstrictor and pressor substances known up to now. They are peptides synthesized and released by vascular endothelial cells. Endothelin 1 (ET 1) is probably most relevant in humans ans is released in response to different endogenous mediators and to mechanical signals like shear stress. ET 1 also potentiates the actions of other vasoconstrictor substances and contributes to the development of some pathophysiologic condition like hypertension, heart failure, vasospasm, and atherosclerosis. Studies using endothelin receptor antagonists show that ET 1 crucialy contributes to the basal blood pressure in healthy humans via its activity on the medial vascular smooth muscle ETA receptors, presented in larger vessels. ETB receptors are more abundant in smaller arteries where there are less ETA receptors. ETA receptors are mediating the development of neointimal formation. ETB receptors are involved in initiation and development of atherosclerotic lesion. The endothelin receptor antagonists lower blood pressure in hypertensive subjects and produce favourable effects on systemic hemodynamics in patients with chronic heart failure. Probable role in preventing atherogenesis makes the endothelin receptor antagonists potentially interesting drugs for the treatment of cardiovascular disease.
Deskriptorji		CORONARY VESSELS ENDOTHELINS RECEPTORS, ENDOTHELIN ENDOTHELIN-1 CORONARY ARTERIOSCLEROSIS