Avtor/Urednik		Lenasi, Helena
Naslov		Vpliv redne telesne aktivnosti na vazodilatacijsko odzivnost mikrožilja v koži
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 49
Jezik		slo
Abstrakt		Regular physical exercise leads to important functional adaptations of cardiovascular system. Blood vessels that have been chronically exposed to augmented shear stress due to augmented blood flow exhibit greater endothelium-dependent vasodilation. The aim of our study was to evaluate the effect of regular intense physical training on microvascular reactivity of human skin. We hypothesized that adaptations concerning endothelial function might occur in human skin microcirculation which during exercise is exposed to greater shear according to its role in thermoregulation. Based on the level of maximal aerobic capacity and resting heart rate two groups of subjects were tested: cyclists competing at national level (n=18) and age-matched controls (n=22). Microvascular blood flow was measured on the dorsal aspect of the hand (area devoid of A-V anastomoses) and on the finger pulp of the middle finger (area rich in A-V anastomoses) using laser-Doppler (LD) method. After 20 minutes of intense bicycle exercise (80 % of maximal aerobic power) LD flux significantly increased in both measured sites. Endothelium-dependent vasodilation was assesed by the application of acetylcholine using iontophoresis on the back of the hand. On the pulp we investigated the parameters of postocclusive reactive hyperaemia (PRH) after 8-minutes occlusion of digital arteries as indexes of endothelial function. Endothelium-independent vasodilation was assesed only on the back of the hand by iontophoretically applied sodium-nitroprusside. The increases in blood flow to the application of acetylcholine were significantly greater in the group of cyclists (7,52-fold +- 2,18 increase in LD flux), as compared to controls (5,86-fold +- 2,09). Abstract truncated at 2000 characters).
Deskriptorji		SKIN MICROCIRCULATION PHYSICAL ENDURANCE HEART RATE VASODILATION LASER-DOPPLER FLOWMETRY HAND ACETYLCHOLINE NITROPRUSSIDE SPORTS