Avtor/Urednik		Dodič-Fikfak, Metoda; Kriebel, David
Naslov		The amphibole theory
Prevedeni naslov		Amfibolna teorija
Tip		članek
Vir		Sanitas et labor
Vol. in št.		Letnik 1, št. 2
Leto izdaje		2001
Obseg		str. 9-25
Jezik		eng
Abstrakt		Background: Considerable controversy surrounds the question of whether the two different types of asbestos - amphiboles and chrysotile - have different carcinogenic potencies. The "amphibole hypothesis" holds that chrysotile is less likely to cause lung cancer and mesothelioma than are the amphiboles. The ability to clarify it's question is limited by a lack of quantitative data with which to estimate separate dose-response curves for the two fiber types. This work investigated lung cancer risk separately for exposure to chrysotile and amphiboles. The research was conducted in a Slovenian asbestos cement plant in which excellent historical exposure data are available to distinguish the working lifetime exposures of the two broad classes of asbestos fibers for workers in the plant. Methods: Detailed historical exposure reconstruction and a case control study of lung cancer incidence were conducted. Cases were all incident cases of primary lung cancer from 1964 to 1994 in those who were hired after 1959 and who worked at least' one month between 1964 and 1994. Exposure measurements were available for all exposed jobs beginning in 1961. Cumulative lifetime exposures to amphiboles and to chrysotile were estimated separately for all cases and controls. Exposure histories were completed on all cases and controls. For each of 58 cases, 5 controls were selected and matched by date of birth and gender. Smoking data were obtained from all but one subject using questionnaire. Logistic regression models were used to estimate separate exposure-response curves for the two fiber types, controlling for smoking. Results: In the period more than I S years before diagnosis smokers above the 90%ile of either chiysotile (OR=1.8, 95% CI=0.7 - 4.7) or amphibole (OR = 2:2, 95% CI = 0.9S:S)'had a somewhat higher risk than those with Lower exposure. (Abstract truncated at 2000 characters).
Izvleček		Izhodišča: Še vedno se postavlja kontroverzno vprašanje ali sta dva tipa azbesta - krizotil in amfiboli - različno močna karcinogena. Amfibolna teorija trdi, da je manj verjetnosti, da krizotil povzroča nastanek pljučnega raka in mezotehoma kot amfiboli. Razjasnitev tega vprašanja je omejena zaradi pomanjkanja kvantitativnih podatkov, ki bi za dve različni vlakni določila ločeno doza-odgovor krivuljo. To delo raziskuje tveganje za razvoj pljučnega raka ločeno za izpostavljenost krizotilu in amfibolom. Raziskava je bila narejena v slovenski cement-azbestni tovarni, ki je imela na voljo odlične zgodovinske podatke, ki so omogočili določitev življenjske izpostavljenosti delavcev za dva različna tipa vlaken. Metode: Narejena je bila natančna rekonstrukcija izpostavljenosti in primer kontrola študija za pljučni rak. Kot primere smo šteli vse na novo pojavljene primere primarnega pljučnega raka od leta 1964 do 1994 pri delavcih, ki so bili zaposleni po letu 1959 in ki so delali najmanj en mesec med letoma 1964 in 1994. Meritve izpostavljenosti so bile na voljo za vsa izpostavljena delovna mesta od leta 1961 dalje. Kumulativna življenjska izpostavljenost amfibolom in krizotilu je bila izračunana ločeno za primere in kontrole. Podatki o zgodovini dela so dobljeni za vse primere in kontrole. Za vsakega od 58 primerov smo izbrali 5 kontrol, ki so bile usklajene s primeri z datumom rojstva in spolom. Podatki o kajenju so bili zbrani z vprašalnikom za vse subjekte, razen za enega. Za določanje doza - učinek odgovorov za dva ločena tipa vlaken, je bila uporabljena logistična regresija s kontrolo kajenja. Rezultati: V času več.kot 15 let pred diagnozo so imeli kadilci, ki so bili izpostav jeni kumulativni izpostav jenosti več kot 90%-ilom krizotila (RO=1.8, 95% ZI= 0.7-4.7) ali več kot 90%-ilom kumulativne doze amfibola (RO = 2.2, 95% ZI= 0.9-5.5) večje tveganje kot tisti, ki so bili manj izpostavljeni. (Izvleček skrajšan pri 2000 znakih)
Deskriptorji		ASBESTOS, AMPHIBOLE OCCUPATIONAL EXPOSURE LUNG NEOPLASMS MESOTHELIOMA SMOKING CASE-CONTROL STUDIES