Avtor/Urednik		Jarc-Vidmar, M; Popović, P; Hawlina, M; Brecelj, J
Naslov		Pattern ERG and psychophysical functions in Best's disease
Tip		članek
Vir		Doc Ophthalmol
Vol. in št.		Letnik 103, št. 1
Leto izdaje		2001
Obseg		str. 47-61
Jezik		eng
Abstrakt		The aim of the study was to asses the neurosensory retinal function in 12 patients (24 eyes) with different stages of Best's disease, by determining how pattern and full field flash ERG responses were related to visual acuity, stage of disease and extent of visual field loss. All patients had typically abnormal EOG responses and normal full field-flash ERG responses. Patients were stratified in two groups according to visual acuity. In the first group 12 eyes with visual acuity better than 0.5, all amplitudes and latencies of PERG P50 and N95 responses were in the normal range. Small central scotoma was detected by static perimetry in four of these eyes. In the second group of 12 eyes with visual acuity 0.5 or less, PERG showed reduced both P50 and N95 amplitudes in five eyes, and N95 solely, in two eyes. All patients had central scotomas detected by static perimetry. Progression of the isease, seen in deterioration of visual acuity and progression of central visual field defects, corresponded well with reduction of both PERG P50 and N95 amplitudes. There was no correlation found between visual acuity and EOG responses. Our results show that in Best's distrophy, pattern ERG is getting abnormal with progression of the disease, indicating relative preservation of neurosensory retina in initial stages of the disease. In contrast to EOG - being abnormal in all the patients regardless of the stage of disease - and full field-flash ERG - being normal in most of the patients - PERG gives opportunity for electrophysiological determination of the progression of the disease.
Deskriptorji		MACULAR DEGENERATION ELECTROOCULOGRAPHY ELECTRORETINOGRAPHY VISUAL ACUITY PERIMETRY SCOTOMA VISUAL FIELDS