Avtor/Urednik		Vlaisavljević, Veljko; Kovačič, Borut; Gavrić-Lovrec, Vida; Reljič, Milan; Petrovič, Vidka; Čižek-Sajko, Mojca; Kovač, Vilma
Naslov		Vpliv izbire zarodkov, spočetih z vnosom semenčice v citoplazmo jajčne celice, na vgnezditev zarodkov po prenosu v maternico
Prevedeni naslov		Influence of embryo selection after intracytoplasmic sperm injection on implantation after embryotransfer
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 71, št. Suppl 1
Leto izdaje		2002
Obseg		str. I-7-11
Jezik		slo
Abstrakt		Background. The aim of our study was to analyse the results of ICSI procedure with respect to the number of embryos transferred 3 or 5 days after fertilization. Methods. The outcome of 1498 day 3 embryo transfers and 364 day 5 embryo (blastocyst) transfers was analysed. The percentage of implanted embryos was compared with regard to the number and quality of embryos transferred. Differences in pregnancy rate between the groups were established with the chi-square test Results. Implantation occurred in 21.3% (320/1498) of embryos transferred to the uterus on day 3 post fertilization. In the transfer of one, two, three or four embryos, the pregnancy rate increased from 20.0% to 22.1%, 54.5% and 59.0% respectively. In the group with one or two embryos for transfer, the pregnancy rate did not change statistically significantly in correlation with embryo quality. The twin pregnancy rate after the transfer of two good quality embryos was 66.6% (8/12). The presence of at least onegood quality embryo among three or four embryos transferred had a statistically significant effect on the singleton pregnancy rate (37.8% and 41.3 %). The rate of multiplepregnancies remained low (18.1 % and 16 6%). Increasing the percentage of good quality embryos for transfer to three or four had a greater effect on the percentage of multiple implantations (43.1% and 54.5%) than on the pregnancy rate (55.5% and 75.8%). After the transfer of 5-day-old embryos (blastocysts), implantation occurred in 37.3% (136/364) of embryos. After the transfer of one blastocyst, the pregnancy rate was 362% (21/58), after the transfer of two blastocysts it was 55.7% (98/176). The twin pregnancy rate after the transfer of two blastocysts amounted to 38.7%. (Abstract truncated at 2000 characters).
Izvleček		Izhodišča. Namen raziskave je bil analizirati rezultate postopka ICSI glede števila in kakovosti zarodkov, ki smo jih prenesli v maternico tri ali pet dni po oploditvi. Metode. Analizirali smo izid prenosa 1498 zarodkov tretji dan po oploditvi in prenosa 364 pet dni starih zarodkov (blastocist). Primerjali smo delež vgnezdenih zarodkov glede na trajanje inkubacije, število in kakovost prenesenih zarodkov. Razlike v stopnji zanositve med posameznimi skupinami smo ugotavljali s testom hi-kvadrat Rezultati. Vgnezdilo se je 22,3 % (320/1498) zarodkov, ki smo jih prenesli v maternico 3 dni po oploditvi. Ob prenosu enega, dveh, treh ali štirih zarodkov se je stopnja zanositev povečevala od 20,0% 22,1 %, 54,5% na 59,0%. V skupini z enim ali dvema zarodkoma za prenos se stopnja zanositve v odvisnosti od kakovosti zarodkov ni spreminjala statistično značilno. Prenos vsaj enega zarodka dobre kakovosti med tremi ali štirimi prenesenimi zarodki je statistično pomembno vplival na stopnjo enoplodne zanositve (37,8% oz. 42,3%). Stopnja večplodnih nosečnosti je ostala nizka (18,1 % oz. 16 6%). Stopnja dvoplodnih zanositev ob prenosu dveh zarodkov dobre kakovosti je bila 66, 6% (8/12). S povečevanjem deleža dobrih zarodkov za prenos na tri ali štiri se je povečeval delež zanositev (55,5% oz. 75,8%), še bolj pa odstotek večplodnih vgnezditev (43,1% oz 54,5%). Po prenosu 5 dni starih zarodkov (blastocist) se je vgnezdilo 37,3% (136/364) zarodkov. Ob prenosu ene blastociste je bila stopnja zanositve 36,2% (21/58), ob prenosu dveh blastocist pa je zanosilo 55,7% (98/176) žensk. Delež dvoplodnih nosečnosti ob prenosu dveh blastocist je bil 38,7%. (Izvleček prekinjen pri 2000 znakih).
Deskriptorji		FERTILIZATION IN VITRO EMBRYO TRANSFER BLASTOCYST PREGNANCY