Avtor/Urednik		Pfeifer, Marija
Naslov		Pomanjkanje rastnega hormona pri odraslih - vpliv nadomestnega zdravljenja z rekombinantnim humanim rastnim hormonom na aterogenezo
Prevedeni naslov		Growth hormone (GH) deficiency in adults - effects of recombinant human GH replacement on atherogenesis
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 95
Jezik		slo, eng
Abstrakt		Human pituitary secretes growth hormone (GH) throughout the lifespan. In adulthood GH is one of the most important regulators of metabolic processes in the human body: it enhances lipolysis and lipid oxidation, protein synthesis and sodium and water retention. It regulates body composition and function. Adults who are deficient in GH exhibit a number of abnormal features including increased adiposity and decreased lean body mass associated with reduced physical fitness. They have increased prevalence of risk factors for atherosclerosis:dyslipidemia, insulin resistance, impaired glucose tolerance, increased fibrinogen, plasminogen activator inhibitor and hypertension. They exhibit increased mortality from cardiovascular, especially cerebrovascular disease. As GH replacement therapy reduced or abolished most of the risk factors for atherosclerosis in hypopituitary GH deficient adults, it was hypothesised that GH replacement would reverse early functional and morphological signs of atherogenesis. Insulin-tolerance test (ITT) is the "gold standard" for assessment of GH reserve. In our study three consecutive ITTs were performed in seven normal adult men and two ITTs in 11 men with hypopituitarism ITTs were performed in seven normal adult men and two ITTs in 11 men with hypopituitarism and suspected GH deficiency. We assessed the reproducibility and variability of GH responses. In normal men the within subject peak GH variability was between 5-60%, and the overall variability in 21 tests was 35%. The lowest peak GH concentration was 27 ug/l. All hypopituitary men had severe GH deficiency (all peak GH concentrations < 1.5 ug/l in both tests). There was a highly significant correlation between individual peak GH values in patients, but not in healthy men. (Abstract truncated at 2000 characters).
Deskriptorji		ATHEROSCLEROSIS SOMATOTROPINS, RECOMBINANT SOMATOTROPIN HYPOPITUITARISM INSULIN RESISTANCE ADULT RISK FACTORS CAROTID ARTERY, COMMON BRACHIAL ARTERY BLOOD PRESSURE BLOOD GLUCOSE LIPIDS LIPOPROTEINS INSULIN-LIKE GROWTH FACTOR I