Avtor/Urednik		Peršuh, Marjan
Naslov		Struktura in vloga adapterske molekule MecA pri Bacillus subtilis
Prevedeni naslov		Structure and function of the adapter molecule MecA in Bacillus subtilis
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 100
Jezik		eng
Abstrakt		Competence for genetic transformation is a physiological state that enables cells to bind and internalize exogenous DNA. In Bacillus subtilis the transcription factor ComK is a key regulator of competence. Using B. subtilis DNA microarrays, we have defined the ComK regulon. Many genes are up-regulated and a few a repressed by ComK. Many of the ComK-induced genes are organized in operons and several are preceded by apparent ComK-box promoter motifs. In addition to previously known genes required for DNA uptake and recombination, other ComK-induced genes that are probably involved in DNA repair and in the uptake and utilization of nutritional sources have been identified. We conclude that the ComK regulon defines a transiently dormant state, of which competence for genetic transformation is only one feature. We suggest the term "K-state" as a broader definition of this stress response. (Abstract truncated at 2000 characters)
Deskriptorji		BACILLUS SUBTILIS TRANSFORMATION, GENETIC TRANSCRIPTION FACTORS PROMOTER REGIONS (GENETICS) GENOME, BACTERIAL HEAT-SHOCK PROTEINS PHENOTYPE ADENOSINE TRIPHOSPHATE BINDING SITES GENOTYPE SPORES, BACTERIAL