Avtor/Urednik		Rot, Uroš
Naslov		Bolniki z multiplo sklerozo z neobičajnimi spremembami v likvorju
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 38
Jezik		slo
Abstrakt		Modern immunomodulatory treatment of MS calls for a better recognition and early diagnosis of MS patiens with uncommon cerebrospinal fluid (CSF) findings. We analyzed clinical features and CSF findings of OT-negative MS and MS with >= 15 mononuclear cells/mm3 comparing OT-negative and OTpositive MS patients and patients with >= 15 CSF mononuclear cells/mm3 and <15 CSF mononuclear cells/mm3, respectively. Retrospective analysis included 233 patients with definite MS. Twenty-six patients had OT-negative MS, 26 patients had MS with >= 15 mononuclear cells/mm3 in CSF. The diagnosis was delayed in OT-negative MS, the average time to diagnosis being 9.21 years (SD 11.24) compared to 4.59 years (SD 5.53) in OT positive MS (p=0.01). The concentration of CSF mononuclear cells was lower, 4.81/ mm3 (SD 4.21) compared to 7.74/ mm3 (SD 7.57); p=0.05, as was IgG level, 9.62% (SD 5.52) compared to 17.19% (SD 9.93) in OT-positive MS p=0.0001. The patients with increased CSF mononuclear cell concentration were diagnosed earlier, the average time to diagnosis being 2.31 years (SD 2.95) compared to 5.46 years (SD 6.84); p=0.02. The patients were more often females and had relapsing-remitting MS (the observation is not statistically significant). They had elevated IgG level, 20.31 % (SD 11.03) compared to 15.18% (SD 9.45); p=0.01. OT-negative MS and MS with increased concentration of CSF mononuclear cells are both found in approximately 10% patients with definite MS. The diagnosis is delayed, because of absence of OT and less active CSF. On the other hand, MS with increased mononuclear cell concentration manifests with more active CSF, what allows an earlier diagnosis. The patients have more often relapsing-remitting MS, which is the form more suitable for introduction of immunomodulatory treatment.
Deskriptorji		MULTIPLE SCLEROSIS MONOCYTES CEREBROSPINAL FLUID PROTEINS IGG AGE FACTORS SEX FACTORS RETROSPECTIVE STUDIES