Avtor/Urednik		Skok, Pavel; Skok, Marija
Naslov		Krvavitve iz zgornje prebavne cevi in nesteroidna protivnetna zdravila (NSAR) - 5-letna prospektivna študija
Prevedeni naslov		Upper gastrointestinal tract hemorrhage and nonsteroidal-antiinflammatory drugs (NSAIDs) - a 5-year prostective study
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 71, št. 3
Leto izdaje		2002
Obseg		str. 153-6
Jezik		slo
Abstrakt		Background. Adverse effects of nonsteroidal antiinflammatory drugs (NSAIDs) are a common cause of digestive tract hemorrhage. Study aims. The purpose of the study was to ascertain the percent of patients taking NSAIDs with upper digestive tract hemorrhage. Type of study. Prospective, analytical. Patients and methods. The study includes in which urgent endoscopic investigations of the upper digestive tract were carried out due to gastrointestinal hemorrhage between 1 January 1994 and 31 December 1998. Results. 3366 patients were investigated: 1222 women and 2144 men; the average age of our patients was 57.5 years (SD+-17.1, a 2-97 year span). In 2905 patients (86.3%) the source of bleeding was confirmed in the upper gastrointestinal tract. Among our patients 55% were aged over 60 years, 26.7% were older than 80 years. Sequelae of peptic ulcer disease were the most significant cause of gastrointestinal hemorrhage, in 47.7% of our patients (1387/2905). In the last week prior to bleeding, 19% of patients (552/2905) were taking regularly NSAIDs, corticosteroids, salycilates or anticoagulant therapy at least in single daily dose. The majority of patients, 94.5% were taking NSAIDs or salycilates. Among NSAIDs they were taking most often ketoprofen, diclofenac or naproxen/naproxen natrium, less often ibuprofen, nabumeton, etodolac or piroxicam. Conclusions. Upper digestive tract hemorrhage is a serious complication of NSAIDs medication, particularly in older patients.
Izvleček		Izhodišča. Neželeni učinki nesteroidnih protivnetnih zdravil (NSAR) so pomemben vzrok za krvavitve iz prebavne cevi. Namen raziskave. Ugotoviti delež bolnikov, ki so zakrvaveli iz zgornje prebavne cevi ob uporabi NSAR. Vrsta raziskave. Prospektivna, analitična. Preiskovanci in načini dela. Študija vključuje bolnike, pri katerih smo v obdobju od 1. januarja 1994 do 31. decembra 1998 opravili endoskopske preiskave zgornjih prebavil zaradi znakov krvavitve iz prebavne cevi. Izsledki. Pregledali smo 3366 bolnikov (1222 žensk in 2144 moških, povprečne starosti 57,5 leta SD+-17,1 v razponu od 2-97). Pri 2905 bolnikih (86,3%) smo ugotovili vir krvavitve v zgornji prebavni cevi. Med našimi preiskovanci je bilo 55% starejših od 60 let, 26,7% starejših od 80 let. Peptična razjeda je bila najpogostejši vzrok krvavitve pri 47,7% preiskovancev (1387/2905). Med preiskovanci je 19% bolnikov (522/2905) v zadnjem tednu pred krvavitvijo redno, vsaj v enkratnem dnevnem odmerku uporabljalo NSAR, kortikosteroide, salicilate ali antikoagulantna zdravila. če pri analizi upoštevamo bolnike, ki so v zadnjih 14 dnevih občasno uporabljali navedena zdravila, je delež teh bolnikov 30% (872/2905 preiskovancev). Večina bolnikov, 94,2% (520/552), je uporabljalo NSAR ali salicilate. Med NSAR so najpogosteje uporabljali: ketoprofen, diklofenak ali naproksen/naproksen natrij, redkeje pa pripravke, kot so ibuprofen, nabumeton, etodolak ali piroksikam. Zaključki. Krvavitve iz zgornje prebavne cevi sodijo med najresnejše zaplete zdravljenja z NSAR, še zlasti pri starejših bolnikih.
Deskriptorji		GASTROINTESTINAL HEMORRHAGE ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL PEPTIC ULCER HEMORRHAGE PROSPECTIVE STUDIES