Avtor/Urednik		Plausteiner, Katarina
Naslov		Kazalci aktivirane koagulacije pri bolnikih z vensko trombozo in mutacijo v genu za protrombin in faktor V
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2001
Obseg		str. 32
Jezik		slo
Abstrakt		Backgroroud: Mutation in prothrombin gene (G20120A) and mutation in factor V gene (G i G91 A), which is reflected as the resistance to activated protein C (nAPC), are important risk factors for thromboembolic disease, because they are presumably connected with activated coagulation. The prevalence of both mutations shows significant geographical distribution. The prevalence of prothrombin mutation is not yet known among patients with deep vein thrombosis in Slovenia. Aim: To determine the prevalence of prothrombin gene mutation in patients with deep vein thrombosis and to study the possible connection between this mutation, mutation in factor V and higher concentrations of markers of activated coagulation: peptid, which is released from prothrombin during its activation to thrombin (F1+2), complex between thrombin and antithrombin (TAT) and degradation products of cross-linked fibrin (D-dimers). Hypothesis: The prevalence of prothrombin mutation is similar to that of the neighbouring populations. Prothrombin mutation and mutation in factor V are connected to higher concentrations of markers of activated coagulation in patients with deep vein thrombosis. Subjects and methods: 88 patients with deep vein thrombosis were included in the retrospective study. DNA was isolated and DNA analysis was performed. Mutation in factor V gene was determined as nAPC. Concentrations of markers of activated coagulation were measured with enzyme immuno assays. (Abstract truncated at 2000 chahacters).
Deskriptorji		THROMBOPHLEBITIS PROTHROMBIN FACTOR V MUTATION PREVALENCE PROTEIN C POLYMORPHISM (GENETICS) POLYMERASE CHAIN REACTION