Avtor/Urednik		Filipič, Metka
Naslov		Razvoj kemoprevencijskih sredstev
Prevedeni naslov		Cancer - mutagenic and antimutagenic substances in food
Tip		članek
Vir		Herbika Ljubl
Vol. in št.		Letnik 3, št. 3
Leto izdaje		2002
Obseg		str. 22-9
Jezik		slo
Abstrakt		The three main factors for human carcinogenesis are: (i) cigarette smoking, (ii) infection and inflammation; and (iii) nutrition and dietary factors. Nutritipn and dietary factors include two categories of factors inftuencing cancer development, namely genotoxic agents implicated in tumour initiation and constituents implicated in tumour promotion and progression. This article describes the genotoxic agents as microcomponents. The most important are mutagens and carcinogens in cooked food (heterocyclic amines), N-nitrozamines and polycyclic aromatic hydrocarbons to which humans are continuously exposed in an ordinary lifestyle. Nutritional factors on the other hand pfay a major role in cancer prevention. In particular, fruit and vegetables contain different substances which have been proven to prevent cancer developing at different stages. These include vitamins, carofens and non-nutritive components like phenoles, indoles etc. Studies of nutrition and dietary conditions together with supplementation of chemopreventive agents will eventually lead us fo cancer prevention, namely delay of the onset of cancer to the late phase of human life, which is called 'natural-end cancer'.
Deskriptorji		NEOPLASMS FOOD CONTAMINATION MUTAGENS HETEROCYCLIC COMPOUNDS AMINES NITROSO COMPOUNDS VITAMINS CAROTENOIDS