Avtor/Urednik		Kariž, Stojan; Kobal, Nataša
Naslov		Poraba protimikrobnih zdravil v Splošni bolnišnici Izola v obdobju 1996-2000
Prevedeni naslov		The usage of antimicrobial drugs at the Izola General hospital from 1996 to 2000
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 41, št. Suppl 2
Leto izdaje		2002
Obseg		str. 67-75
Jezik		slo
Abstrakt		The purpose of this survey was to determine the pattern and trend of antimicrobial usage at the Izola General Hospital from 1996 to 2000 and to evaluate the efficacy of antibiotic formulary restrictions, which were introduced at the beginning of 1999. A separate analysis of antimicrobial consumption at various hospital wards in 2000 was also performed. Drugs from the group J01 according to the ATC classification were included in the study. The results are expressed as the defined daily dose (DDD) per 100 bed days. The total consumption of antimicrobials increased from 37.8 to 42 DDD per 100 bed days (or, by 11.1%). Betalactams were the most commonly used antimicrobial agents (57.8%), followed by quinolones (13.9%), macrolide and pyranoside antibiotics (10.2%) and aminoglycosides (7.8%). The usage of quinolones increased by 65.2% during the observation period. Antibiotic formulary restriction resulted mainly in reduced utilization of third-generation cephalosporins by 37.2% and enhanced utilization of first- and second-generation cephalosporins. Surveillance of antimicrobial drug consumption and efforts to further promote judicious prescribing should be continued in the future.
Izvleček		Z retrospektivno analizo smo želeli prikazati stanje in gibanje porabe protimikrobnih zdravil v Splošni bolnišnici Izola v obdobju 1996-2000 in oceniti uspešnost uvedbe restriktivnega načina naročanja antibiotikov v začetku leta 1999. Za leto 2000 smo ločeno analizirali porabo protimikrobnih zdravil po posameznih bolnišničnih oddelkih. V raziskavi smo zajeli pripravke za sistemsko zdravljenje bakterijskih okužb (skupina J01 po anatomsko-terapevtsko-kemijski razvrstitvi). Porabo zdravil smo opredelili kot dnevni definirani odmerek (DDD) na 100 bolnišnično oskrbnih dni (BOD). Celokupna poraba protimikrobnih zdravil je v opazovanem obdobju porasla s 37,8 na 42 DDD/100 BOD ali za 11,1 %. V povprečju 5 let je prevladovala poraba betalaktamskih antibiotikov s 57,8 % deležem, sledijo kinoloni s 13,9 %, makrolidni in piranozidni antibiotiki z 10,2 % in aminoglikozidi s 7,8 % deležem celokupne porabe. Poraba kinolonov je porasla za 65,2 %. Uvedba restriktivnega načina naročanja se je najbolj odrazila na zmanjšanju porabe cefalosporinov 3. generacije (za 37,2 %) in porastu porabe cefalosporinov 1. in 2. generacije. Tudi v prihodnje si moramo ob spremljanju porabe protimikrobnih zdravil prizadevati za izboljšanje in racionalizacijo antibiotičnega predpisovanja.
Deskriptorji		ANTIBIOTICS DRUG UTILIZATION LENGTH OF STAY BACTERIAL INFECTIONS HOSPITALS, GENERAL CEPHALOSPORINS