Avtor/Urednik		But, I; Takač, I
Naslov		Evaluating the risk of tumor aneuploidy on the basis of preoperative blood flow resistance index (RI) measurements in patients with serous ovarian tumors
Tip		članek
Vir		In: Ben-Rafael Z, Shoham Z, Frydman R, editors. The 2nd world congresss on Controversies in obstetrics gynecology and infertility. Vol 2; 2001 Sep 6-9; Paris. Bologna: Monduzzi editore, International proceedings division,
Leto izdaje		2001
Obseg		str. 131-9
Jezik		eng
Abstrakt		Objective: The aggressiveness of ovarian tumors seems to be in close relation to tumor ploidy. In this retrospective study we tried to establish whether it is possible to predict tumor ploidy on the basis of known preoperative factors, with emphasis on preoperative blood flow resistance index (RI) measurements. Methods: This study includes 59 patients with serous ovarian tumors (6 patients with cystadenoma, 17 with a borderline tumor, and 36 patients with an ovarian carcinoma) in whom the serum CA 125 values and blood flow resistance measurements were preoperatively determined. The suspension of nuclei was prepared from formaline fixed and paraffin embedded tumor tissue according to the Hedley method. DNA content in tumor nuclei was evaluated by means of flow cytometry. For statistical analysis the Mann-Whitney U-test, the forward stepwise multivariate analysis and logistic regression were used. Results: Aneuploidy was determined in 42.4% serous tumors (25/59). Tumor vascularization was present in 54 tumors (91.5%), the average RI values between the aneuploid and diploid group of tumors differed significantly (p= 0.0097) and amounted to 0.36 and 0.48, respectively. RI was significantly connected to tumor ploidy (p=0.0091). The risk of aneuploidy increased 4.9 times when detected RI values were below 0.40, thus amounting to 64.3%. Conclusions: Our results show that RI measurements could be of great importance in the assessment of ovarian tumor aggressiveness, represented by DNA-ploidy.
Deskriptorji		OVARIAN NEOPLASMS NEOPLASM INVASIVENESS ANEUPLOIDY BLOOD FLOW VELOCITY CA-125 ANTIGEN FLOW CYTOMETRY RETROSPECTIVE STUDIES