Avtor/Urednik | Prokšelj, Katja | |
Naslov | Vpliv statinov na učinke L-arginina na endotelno vazomotorno funkcijo pri bolnikih s hiperholesterolemijo | |
Tip | monografija | |
Kraj izdaje | Ljubljana | |
Založnik | Medicinska fakulteta | |
Leto izdaje | 2001 | |
Obseg | str. 45 | |
Jezik | slo | |
Abstrakt | BACKGROUND. Patients with hypercholesterolemia have impaired endothelial function. In endothelial cell nitric oxide is formed from L-arginine and it mediates arterial dilation. L-arginine improves endothelium-dependent vasodilation in patients with hypercholesterolemia. The treatment with statins improves endothelium-dependent vasodilation, however it is not known how the treatment affects L-arginin effects. METHODS. 20 patients with coronary artery disease and untreated hypercholesterolemia have received 20 mg of simvastatin per day for 8 weeks. Clinical examination and blood sample analyses were performed at the beginning of the study and after the 8-week treatment. Total, LDL and HDL cholesterol, tryglicerides, apolipoprotein B, AI and C-reactive protein levels were evaluated. Endothelium-dependent flow mediated and endothelium-independent nitroglycerin-induced vasodilation of the brachial artery were determined with ultrasound. Measurements were obtained at basal conditions and after L-arginine infusion. RESULTS. Total cholesterol, LDL cholesterol (27% and 36%, p<0.0001) and C-reactive protein levels (79%, p<0.001) were significantly reduced after the 8-week treatment with simvastatin. Apolipoprotein B levels had also been reduced, whereas HDL cholesterol, tryglicerides and apolipoprotein AI levels were not affected by statin therapy. Endothelium-dependent vasodilation increased from 4.7% +- 1.6% to 8.5% +- 2.9% (p<0.0001). AT the begining of the study L-arginine supplementation resulted in 130% increase (p<0.0001) of endothelium-dependent vasodilation, whereas the effect of L-arginine supplementation was absent after simvastatin therapy. (Abstract truncated at 2000 characters). | |
Deskriptorji | CORONARY DISEASE HYPERCHOLESTEROLEMIA BRACHIAL ARTERY VASODILATION ANTILIPEMIC AGENTS ENDOTHELIUM, VASCULAR CHOLESTEROL TRIGLYCERIDES LIPOPROTEINS, HDL CHOLESTEROL LIPOPROTEINS, LDL CHOLESTEROL APOLIPOPROTEINS A APOLIPOPROTEINS B C-REACTIVE PROTEIN NITROGLYCERIN ARGININE |