Avtor/Urednik		Tarle, M; Frković-Grazio, S; Kraljić, I; Kovačič, K
Naslov		A more objective staging of advanced prostate cancer-routine recognition of malignant endocrine structures: the assessment of serum TPS, PSA, and NSE values.
Tip		članek
Vir		Prostate
Vol. in št.		Letnik 24, št. 3
Leto izdaje		1994
Obseg		str. 143-8
Jezik		eng
Abstrakt		Bone scans, serum tissue-specific polypeptide antigen (TPS), prostate specific antigen (PSA), and neuron-specific enolase (NSE) were assessed in a total of 80 hormonally treated prostate cancer patients. Thirty-nine patients were free of osseous lesions; in 8 subjects, 3 or fewer scintigraphic hot spots were found; in 29 patients, more than 3 bone lesions were recorded. In 3 patients, a partial contribution of endocrine cell cancer structures was found, while in one patient, a homogeneous small cell carcinoma was detected at autopsy. Measurement of the serum PSA test showed a clear-cut rise from stage D0 subjects to stage D2 patients, with a small number of bone lesions (> or = 3). However, a relative decrease in the mean PSA level was measured with further progression in a number of hot spots in bone (> 3). Androgen threshold that is critical for the induction of the PSA (and PAP) expression seems to differ markedly in various cell subpopulations that arise during adenocarcinoma dedifferentiation. This fact explains not only the rise in serum PSA in the majority of progressive and previously castrated subjects after an initial period of hormonal responsiveness, but also a relative declineof androgen-dependent PSA expression with further tumor progression. Localized disease was accompanied with normal or just slightly elevated TPS concentration. In metastatic tumors, serum TPS values revealed a steady increase with the progression in bone. These data seem to reflect not only an increase in tumor proliferation rate with progressively transformed genome, but also the rise in the number of proliferating cells. The presence of nonepithelial transformed tumor structures, such as small cell cancer within a bulk of adenocarcinoma, reduces or normalizes numerical serotests values of both TPS and PSA even during tumor progression. The extent of such decline depends upon the bulk of the endocrine component. (Abstract truncated at 2000 characters).
Deskriptorji		PROSTATIC NEOPLASMS NEOPLASMS, MULTIPLE PRIMARY ADENOCARCINOMA BONE NEOPLASMS MIDDLE AGE TUMOR MARKERS, BIOLOGICAL TISSUE POLYPEPTIDE ANTIGEN TESTOSTERONE PROSTATE-SPECIFIC ANTIGEN PHOSPHOPYRUVATE HYDRATASE PEPTIDES NEOPLASM STAGING LUNG NEOPLASMS LIVER NEOPLASMS IMMUNOHISTOCHEMISTRY CHROMOGRANINS CARCINOMA, SMALL CELL CARCINOID TUMOR ANTIGENS, NEOPLASM