Avtor/Urednik     Videčnik, Jerneja; Zorman, Peter
Naslov     Klinične in epidemiološke značilnosti bolnikov z erythema migrans
Prevedeni naslov     Clinical and epidemiological charactersitics of patients with erythema migrans
Tip     članek
Vir     Med Razgl
Vol. in št.     Letnik 40, št. 4
Leto izdaje     2001
Obseg     str. 383-400
Jezik     slo
Abstrakt     Lyme borreliosis is endemic in Slovenia. Its incidence has been on the increase over the past decade, and is among the highest in Europe. Erythema migrans is the clinical hallmark of Lyme borreliosis. It is estimated that this sign is present in approximately three-quarters of patients during the early course of the disease. Typical erythema migrans is the only clinical findings that enables a reliable diagnosis of Lyme borreliosis. The presence of erythema migrans alone is a sufficient indicator for the initiation of antibiotic therapy, which is especially efficient early in the course of the disease. This study presents clinical and epidemiological findings in adult patients with erythema migrans who were diagnosed at the Lyme Borreliosis Outpatient Clinic, Department of Infectious Diseases, University Medical Center, Ljubljana in 2000. These findings were compared with data obtained using the same approach for an identical group of patients in 1993. It was expected that the knowledge base on Lyme borreliosis would be superior in 2000 compared to 1993; it was also hypothesized that patients would visit the Clinic earlier in the course of the disease, and consequently present with smaller skin lesions and fewer systemic complaints. The study was prospective. Patients who qualified for inclusion in the study were at least 15 years of age, diagnosed with typical erythema migrans in 1993 and 2000 at the Lyme Borreliosis Outpatient Clinic in Ljubljana. The diagnosis of erythema was established clinically according to the modified criteria proposed by the CDC (Centers for Disease Control). (Abstract truncated at 2000 characters).
Izvleček     Lymska borelioza je v Sloveniji endemična bolezen. Pojavnost je v zadnjih desetih letih močno narasla in je med najvišjimi v Evropi. Erythema migrans je v poteku bolezni daleč najbolj pogost klinični znak. Ocenjujejo, da se pojavlja pri približno treh četrtinah bolnikov z lymsko boreliozo v zgodnjem obdobju bolezni. Erythema migrans tipičnega izgleda je edini znak, ki v vsakdanji klinični praksi omogoča dokaj zanesljivo postavitev diagnoze lymske borelioze. Kot tak je zadosten kriterij za pričetek antibiotičnega zdravljenja, s katerim z veliko gotovostjo preprečimo nadaljni razvoj bolezni in močno zmanjšamo pojavnost poznih zapletov bolezni. Predstavili smo klinične in epidemiološke značilnosti odraslih bolnikov z diagnozo erythema migrans, ki so bili pregledani v Ambulanti za lymsko boreliozo na Kliniki za infekcijske bolezni in vročinska stanja v Ljubljani v letu 2000. Dobljene podatke smo primerjali z rezultati podobne raziskave, ki je na isti kliniki potekala v letu 1993. Predpostavili smo, da se je poznavanje bolezni od leta 1993 do leta 2000 povečalo. Zato smo pričakovali, da bodo bolniki v letu 2000 prihajali na pregled bolj zgodaj v poteku bolezni in da bodo zaradi tega kožne spremembe ob pregledu manjše ter dodatni bolezenski znaki manj pogosto prisotni. V prospektivno raziskavo, ki je potekala v letih 1993 in 2000, smo vključili vse bolnike starejše od 15 let z diagnozo erythema migrans. Značilna kožna sprememba je morala ustrezati modificiranim kriterijem CDC (Centers for Disease Control). Epidemiološke in klinične podatke smo beležili s standardnim vprašalnikom. Za primerjavo kvantitativnih podatkov smo uporabili Kruskall-Wallisov test, za primerjavo kvalitativnih pa test hi-kvadrat oziroma Fisherjev test. (Izvleček prekinjen pri 2000 znakih).
Deskriptorji     LYME DISEASE
ERYTHEMA CHRONICUM MIGRANS
PROSPECTIVE STUDIES
TICKS
BITES AND STINGS