Avtor/Urednik		Schibler, A; Hall, GL; Businger, F; Reinmann, B; Wildhaber, JH; Černelč, M; Frey, U
Naslov		Measurement of lung volume and ventilation distribution with an ultrasonic flow meter in healthy infant
Tip		članek
Vir		Eur Respir J
Vol. in št.		Letnik 20, št. 4
Leto izdaje		2002
Obseg		str. 912-8
Jezik		eng
Abstrakt		Small airway disease in infants is characterised by abnormal lung volume and uneven ventilation distribution. An inert tracer gas washin/washout technique using a pulsed ultrasonic flow meter is presented to measure functional residual capacity (FRC) and ventilation distribution in spontaneously breathing and unsedated infants. With a pulsed ultrasound sent through the main stream of the flow meter, flow, volume and MM of the breathing gas can be calculated. Sulphur hexafluoride was used as a tracer gas. In a mechanical lung model (volume range 53-188 mL) and in 12 healthy infants (aged 38.3+-9.2 days; mean+-SD) accuracy and reproducibility of the technique was assessed. Indices of ventilation distribution such as alveolar-based mean dilution number (AMDN) and pulmonary clearance delay (PCD) were calculated. Mean error of volume measurement in the lung model was 0.58% (coefficient of variance (CV) 1.3%). FRC was in the low predicted range for normal infants (18.0 +- 2.0 mL . kg -1) and highly reproducible (5.5 +- 1.7% intra-subject CV). AMDN was 1.63 +- 0.15 and PCD was 52.9 +- 11.1%. Measurement of functional residual capacity and ventilation distribution using a sulphur hexafluoride washin/washout and an ultrasonic flow meter proved to be highly accurate and reproducible in a lung model and in healthy, spontaneously breathing and unsedated infants.
Deskriptorji		FUNCTIONAL RESIDUAL CAPACITY SULFUR HEXAFLUORIDE INFANT ULTRASONOGRAPHY, DOPPLER, PULSED MODELS, ANATOMIC