Avtor/Urednik		Arnež, Maja; Pleterski-Rigler, Dušica; Lužnik-Bufon, Tatjana; Ružić-Sabljić, Eva; Strle, Franc
Naslov		Solitary erythema migrans in children: comparison of treatment with azithromycin and phenoxymethylpenicillin
Tip		članek
Vir		Wien Klin Wochenschr
Vol. in št.		Letnik 114, št. 13-14
Leto izdaje		2002
Obseg		str. 498-504
Jezik		eng
Abstrakt		Objective: To compare clinical effectiveness and side effects of treatmenf with azithromycin or phenoxymethylpenicilin in children with solitary erythema migrans. Methods: Consecutive patients younger than 15 years, referred to our institution ih 1998 and 1999 with previously untreated typical solitary erythema migrans, were included in This prospective study. Basic demographic features and .clinical data were collected by means of a questionnaire. The efficiency of treatment of acute disease, development of later major and/or minor manifestations of Lyme borreliosis and side effects of treatment were surveyed by follow-up visits during the first year. Results: Forty-two patients received azithromycin 20 mg/kg/day for the first day followed by 10 mg/kg/day for a further four days and phenoxymethylpenicillin 100000 IU/kg/day for 14 days. No differences in demographic and clinical pre-treatment characteristics were present in the two groups, with the exception of the duration of erythema migrans before treatment (3 days in the azithromycin group versus 4 days in the phenoxymethylpenicillin group; p=0.0320). The clinical course during the post-treatment period revealed no significant differences between the two groups in the duration of EM (3 days versus 4 days; p=0.2471), the appearance of minor manifestations of Lyme borreliosis (17.5% in the azithromycin group versus 24.4% in the phenoxymethylpenicillin group; p=0.6252), or in the emergence of major manifestations of Lyme borreliosis (one patient in each treatment group). One year after antibiotic treatment all patients were asymptomatic. Side effects of treatment were observed in 5.3% of patients treated with azithromycin and in 6% treated with phenoxymethylpenicillin. The appearance of "Herxheimer's reaction" at the beginning of treatment was recorded in 7 out of 42 patients (6%) in each treatment group. (Abstract truncated at 2000 characters)
Deskriptorji		ERYTHEMA CHRONICUM MIGRANS AZITHROMYCIN PENICILLIN V BORRELIA BURGDORFERI CHILD TREATMENT OUTCOME