Avtor/Urednik     Maraspin, Vera; Cimperman, Jože; Lotrič-Furlan, Stanka; Ružić-Sabljić, Eva; Jurca, Tomaž; Picken, Roger N; Strle, Franc
Naslov     Solitary borrelial lymphocytoma in adult patients
Tip     članek
Vir     Wien Klin Wochenschr
Vol. in št.     Letnik 114, št. 13-14
Leto izdaje     2002
Obseg     str. 515-23
Jezik     eng
Abstrakt     During the period from 1986 to 2000, 85 adult patients with solitary borrelial lymphocytoma were diagnosed at the Department of Infectious Diseases, University Medical Centre Ljubljana, Slovenia. There were 36 (42.4%) females and 49 (57.6%) males with a median age of 49 (15-74) years. Borrelial lymphocytoma was located on the breast (nipple - areola mammae region) in 68 (80%) patients, on the ear lobe in eight (9.4%), and in other locations in nine (10.6%). A concomitant erythema migrans enabling clinical diagnosis of Lyre borreliosis was registered or reported in 67 (78.8%) patients. Fifteen (17.6%) patients had no accompanying symptoms, 34 (40%) reported local and constitutional symptoms, 23 (27.1%) recounted only local symptoms, and 13 (15.3%) patients had solely constitutional symptoms. Clinical findings indicating early disseminated borrelial infection were observed at the first visit in 12 (14.1 %) patients: six (7.1 %) had multiple erythema migrans, one had meningitis, one meningoradiculitis and arthritis, one radiculoneuritis and arthritis, one peripheral facial palsy and concomitant meningitis, and two arthritis. In addition, one of the patients with borrelial lymphocytoma on the breast had acrodermatitis chronica atrophicans. A seropositive response to borrelial antigens was found in 30 (35.3%) patients at the initial examination. In 11/46 (23.9%) patients, infection with Borrelia burgdorferi sensu lato was confirmed by isolation of the agent from lymphocytoma tissue. Eight out of nine (88.9%) typed borrelial strains were found to be 8. afzelii, and one (11.1 %) 8. bissettii. Patients were treated with doxycycline, azithromycin, amoxycillin, cefuroxime-axetil, phenoxymethylpenicillin, or ceftriaxone. (Abstract truncated at 2000 characters)
Deskriptorji     LYME DISEASE
BORRELIA BURGDORFERI
PSEUDOLYMPHOMA
ANTIBODIES, BACTERIAL
ADULT
PROSPECTIVE STUDIES