Avtor/Urednik		Arnež, Maja; Pleterski-Rigler, Dušica; Lužnik-Bufon, Tatjana; Ružić-Sabljić, Eva; Strle, Franc
Naslov		Children with multiple erythema migrans: are there any pre-treatment symptoms and/or signs suggestive for central nervous system involvement?
Tip		članek
Vir		Wien Klin Wochenschr
Vol. in št.		Letnik 114, št. 13-14
Leto izdaje		2002
Obseg		str. 524-9
Jezik		eng
Abstrakt		Objective: To establish eventual signs and symptoms suggestive for central nervous system involvement in children with multiple erythema migrans. Methods: Patients younger than 15 years with multiple erythema migrans, diagnosed at our department from 1996 to 2000, were included in this prospective study. Demographic, clinical and laboratory findings were obtained and compared for a group of patients with pleocytosis (interpreted as a sign of central nervous system involvement) and a group of children with normal cerebrospinal fluid findings. Results: Cerebrospinal fluid pleocytosis (cell counts >_5x108/I) was detected in 55/214 (25.7%) children; it was lymphocytic in 94.5% of patients and ranged from 5 to 320 (median, 10 x 1 O6/I). Compared with the group with normal cerebrospinal fluid findings, patients with pleocytosis more often reported having had Lyme borreliosis in the past (8/55 versus 3/159; p=0.0011), had longer incubation periods (25.5 versus 14 days; p=0.0269), larger diameter of the largest erythema migrans at the time of first examination (10 versus 5.5 cm; p=0.0055), higher frequency of associated systemic symptoms (45.5% versus 21.4%; p=0.0011), positive meningeal signs (10.9% versus 1.9%; p=0.0100), borrelial IgG antibodies in cerebrospinal fluid (3/49 versus 0/150; p=0.0142) and 8. burgdorferi s.l. isolated from cerebrospinal fluid (7/52 versus 1/147; p=0.0004), but less often had mild initial disease (67.3% versus 88.7%; p=0.0006). (Abstract truncated at 2000 characters)
Deskriptorji		ERYTHEMA CHRONICUM MIGRANS BORRELIA BURGDORFERI LYME DISEASE ANTIBODIES, BACTERIAL IGG CHILD CENTRAL NERVOUS SYSTEM DISEASES