Avtor/Urednik		Pompe-Kirn, Vera
Naslov		Epidemiological features of laryngeal cancer in Slovenia
Prevedeni naslov		Epidemiološke značilnosti raka grla v Sloveniji
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 71, št. Suppl 3
Leto izdaje		2002
Obseg		str. III-59-63
Jezik		eng
Abstrakt		Background. In Slovenia laryngeal center incidence increased in men in the 50s, 60s and 70s and was rather stable afterwards, while in women the increase was more evident in the 80s and 90s. In order to better understand the trends in incidence in the 80s and 90s as well as the survival of laryngeal cancer patients, we analyzed the data by subsites (glottis and other parts of larynx), and considered the phenomenon of field cancerisation. In addition, projection of laryngeal cancer incidence till the year 2009 was calculated. Methods. The basic source of information was the data of the Cancer Registry of Slovenia. Standard and special methods of descriptive epidemiology were used (the APC model, the person-years approach, Hakulinens package for the survival analysis). Results. In the period 1980-1999, in men there was an increase of glottic carcinoma incidence during the whole 20 years, a decrease of supraglottic carcinoma in the period 1996-1999, and no change in the incidence of not defined subsites. The ratio sipraglottis vs. glottis has been changing in favor of glottis carcinoma. The percentage of localized diseases at diagnosis of all subsites is slightly improving. For patients with glottic carcinoma diagnosed in 1993-1997 the relative five year survival was 87% while for patients with cancer of other defined subsites of the larynx (in 86% supraglottis, 4% subglottis and 10% overlapping lesions) it was 41%. Conclusions. Our prediction till 2009 is a small increase of the incidence in laryngeal cancer in men as well as in women. But also a better survival of patients could be expected. Fur ther efforts for a more efficient primary as well as secondary prevention are needed.
Izvleček		Izhodišča. V Sloveniji je incidenca raka grla pri moških naraščala še v 50., 60. in 70. letih; kasneje se je bolj ali manj ustalila. Pri ženskah je očitno naraščala Šele v 80. in 90. letih. Da bi bolje razumeli incidenco in preživetje bolnikov z rakom grla v 80. in 90. letih, je avtorica v tem prispevku obdelala podatke glede na podlokacijo raka v grlu (glasilke in ostale lokacije) in upoštevala pojav področne karcinogeneze. Izračunali so še projekcijo incidence raka grla do leta 2009. Metode. Podatke je avtorica črpala iz podatkovne baze Registra raka za Slovenijo. Uporabila je standardne in posebne metode deskriptivne epidemiologije (model APC (age-period-cohort)), analizo osebe-leta in Hakulinenov računalniški program za izračun preživetja). Izsledki. V letih 1980-1999 se je pri moških karcinoma glasilk ves čas večala, incidenca supraglotičnega karcinoma je v letih 1996-1999 upadala, incidenca raka neopredeljene lokacije v grlu pa se ni spremenila. Razmerje supraglotični karcinom nasproti karcinomu glasilk se je spreminjalo v prid karcinomu glasilk. Odstotek omejene bolezni se je zmerno povečal. Pri bolnikih, zbolelih v letih 1993-1997 za rakom glasilk, je bilo relativno petletno preživetje 87 odstotno, pri tistih, ki so zboleli za rakom drugih podlokacij v grlu, pa 41 odstotno. Zaključki. Predvidevamo, da se bo do leta 2009 incidenca raka grla pri moških in pri ženskah še nekoliko povečala. Pričakujemo lahko boljše preživetje bolnikov. Nadalnji programi učinkovitejše primarne in sekundarne preventive so še vedno potrebni.
Deskriptorji		LARYNGEAL NEOPLASMS INCIDENCE SURVIVAL ANALYSIS SLOVENIA