Avtor/Urednik		Stegnar, Mojca
Naslov		Hiperhomocisteinemija in žilna bolezen
Prevedeni naslov		Hyperhomocysteinemia and vascular disease
Tip		članek
Vir		Farm Vestn
Vol. in št.		Letnik 53, št. Poseb št
Leto izdaje		2002
Obseg		str. 343-6
Jezik		slo
Abstrakt		Moderately elevated level of homocysteine (moderate hyperhomocysteinemia) is recognised as a risk factor for vascular disease such as coronary heart disease, peripheral arterial occlusive disease, ischaemic cerebrovascular disease and venous thrombosis. Pathological mechanisms inducing increased risk due to homocysteine are not elucidated, and are based on the presumption that homocysteine shows prothrombotic effects and alters vascular function. Although retrospective studies showed increased risk associated with moderate hyperhomocysteinemia, prospective studies failed to provide unequivocal prove of association between increased homocysteine and vascular disease. If this association will be shown in future, it will have significant impact in prevention of vascular disease.
Izvleček		Zmerno povečana koncentracija homocisteina (zmerna hiperhomocisteinemija) je spoznana kot dejavnik tveganja za žilno bolezen, kot je koronarna srčna bolezen, okluzivna bolezen perifernih arterij, ishemična cerebrovaskularna bolezen in venska tromboza. Vendar pa patološki mehanizmi po katerih homocistein povečuje tveganje za razvoj žilnih bolezni niso znani, osnovani pa so na predpostavki, da ima homocistein protrombotičen učinek in da spreminja žilno funkcijo. Čeprav so retrospektivne raziskave na bolnikih pokazale kakšno tveganje za žilno bolezen predstavlja zmerna hiperhomocisteinemija, pa prospektivne študije ne nudijo nedvomnega dokaza o povezavi med zvišanim homocisteinom in žilno boleznijo. Če bo povezava v bodočnosti dokazana, bo to imelo velik vpliv na preprečevanje žilnih bolezni.
Deskriptorji		ATHEROSCLEROSIS THROMBOSIS ENDOTHELIUM, VASCULAR HOMOCYSTEINE